NEK3 anticorps (N-Term)

N° du produit ABIN2783629

Détail du produit anti-NEK3 anticorps

Antigène: NEK3 (NIMA related kinase 3 (NEK3))

Épitope: N-Term

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Cobaye, Cheval, Lapin, Saccharomyces cerevisiae, Poisson zèbre (Danio rerio)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NEK3 est non-conjugé

Application: Western Blotting (WB)

Séquence: FTQMCLGVNH IHKKRVLHRD IKSKNIFLTQ NGKVKLGDFG SARLLSNPMA

Homologie: Cow: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 93%, Rabbit: 100%, Rat: 93%, Yeast: 79%, Zebrafish: 86%

Attributs du produit: This is a rabbit polyclonal antibody against NEK3. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human NEK3

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 506 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur NEK3

Antigène: NEK3 (NIMA related kinase 3 (NEK3))

Autre désignation: NEK3 (NEK3 Produits)

Synonymes: anticorps HSPK36, anticorps ATNEK3, anticorps NIMA-RELATED KINASE3, anticorps NIMA-related kinase 3, anticorps T8M17.60, anticorps T8M17_60, anticorps NIMA related kinase 3, anticorps NIMA (never in mitosis gene a)-related expressed kinase 3, anticorps NIMA-related kinase 3 S homeolog, anticorps NIMA-related kinase 3, anticorps NEK3, anticorps Nek3, anticorps nek3.S

Sujet: NEK3 is a member of the NimA (never in mitosis A) family of serine/threonine protein kinases. It differs from other NimA family members in that it is not cell cycle regulated and is found primarily in the cytoplasm. The kinase is activated by prolactin stimulation, leading to phosphorylation of VAV2 guanine nucleotide exchange factor, paxillin, and activation of the RAC1 GTPase.In Aspergillus nidulans, lack of the serine/threonine kinase NimA (never in mitosis A) results in cell cycle arrest in G2, while overexpression causes the premature onset of mitotic events. The protein encoded by this gene is similar in sequence to the Aspergillus nidulans protein and may therefore play a role in mitotic regulation. However, the encoded protein differs from other NimA family members in that it is not cell cycle regulated and is found primarily in the cytoplasm. Three transcript variants have been found for this gene, but the full-length nature of only two of them has been characterized.
Alias Symbols: HSPK36, MGC29949
Protein Interaction Partner: HDAC6, NMNAT1, CDCA8, BPGM, VAV2, PRLR, VAV1, CSN2,
Protein Size: 506

Poids moléculaire: 58 kDa

ID gène: 4752

NCBI Accession: NM_002498, NP_002489

UniProt: P51956