ZP4 anticorps (N-Term)

N° du produit ABIN2783828

Cet anticorps anti-ZP4 Polyclonal Lapin (ABIN2783828) détecte spécifiquement ZP4 dans WB. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour ZP4 anticorps (N-Term) (ABIN2783828)

Antigène: ZP4 (Zona Pellucida Glycoprotein 4 (ZP4))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ZP4 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-ZP4 anticorps

Épitope: N-Term

Fonction: ZP4 Antibody - N-terminal region

Séquence: MWLLRCVLLC VSLSLAVSGQ HKPEAPDYSS VLHCGPWSFQ FAVNLNQEAT

Homologie: Human: 100%

Attributs du produit: This is a rabbit polyclonal antibody against ZP4. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human ZP4

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP49639-100UG

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: prevent freeze-thaw cycles

Stock: 4 °C,-20 °C

Stockage commentaire: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Détails sur ZP4

Antigène: ZP4 (Zona Pellucida Glycoprotein 4 (ZP4))

Autre désignation: ZP4

Sujet:

Background Information: The zona pellucida is an extracellular matrix that surrounds the oocyte and early embryo. It is composed primarily of three or four glycoproteins with various functions during fertilization and preimplantation development. It is hypothesized that furin cleavage results in release of the mature protein from the plasma membrane for subsequent incorporation into the zona pellucida matrix.The zona pellucida is an extracellular matrix that surrounds the oocyte and early embryo. It is composed primarily of three or four glycoproteins with various functions during fertilization and preimplantation development. The nascent protein contains a N-terminal signal peptide sequence, a conserved ZP domain, a consensus furin cleavage site, and a C-terminal transmembrane domain. It is hypothesized that furin cleavage results in release of the mature protein from the plasma membrane for subsequent incorporation into the zona pellucida matrix. However, the requirement for furin cleavage in this process remains controversial based on mouse studies. Previously, this gene has been referred to as ZP1 or ZPB and thought to have similar functions as mouse Zp1. However, a human gene with higher similarity and chromosomal synteny to mouse Zp1 has been assigned the symbol ZP1 and this gene has been assigned the symbol ZP4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

Gene Name: Zona pellucida glycoprotein 4

Alternative Symbols: ZBP, ZP1, ZPB, Zp-4

Protein Name: Zona pellucida sperm-binding protein 4

Poids moléculaire: 49kDa

ID gène: 57829

NCBI Accession: NP_067009

UniProt: Q12836