ANTXR1 anticorps (Middle Region)

N° du produit ABIN2784026

L’anticorps Lapin Polyclonal anti-ANTXR1 a été validé pour WB. Il convient pour détecter ANTXR1 dans des échantillons de Humain, Souris, Rat, Chien, Lapin, Boeuf (Vache), Cobaye et Cheval.

Aperçu rapide pour ANTXR1 anticorps (Middle Region) (ABIN2784026)

Antigène: ANTXR1 (anthrax Toxin Receptor 1 (ANTXR1))

Reactivité: Humain, Souris, Rat, Chien, Lapin, Boeuf (Vache), Cobaye, Cheval

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ANTXR1 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-ANTXR1 anticorps

Épitope: Middle Region

Séquence: VRWGEKGSTE EGAKLEKAKN ARVKMPEQEY EFPEPRNLNN NMRRPSSPRK

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%

Attributs du produit: This is a rabbit polyclonal antibody against ANTXR1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human ANTXR1

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 564 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur ANTXR1

Antigène: ANTXR1 (anthrax Toxin Receptor 1 (ANTXR1))

Autre désignation: ANTXR1

Sujet: ANTXR1 is a type I transmembrane protein and is a tumor-specific endothelial marker that has been implicated in colorectal cancer. ANTXR1 has been shown to also be a docking protein or receptor for Bacillus anthracis toxin, the causative agent of the disease, anthrax. The binding of the protective antigen (PA) component, of the tripartite anthrax toxin, to this receptor protein mediates delivery of toxin components to the cytosol of cells. Once inside the cell, the other two components of anthrax toxin, edema factor (EF) and lethal factor (LF) disrupt normal cellular processes.The protein encoded by this gene is a type I transmembrane protein and is a tumor-specific endothelial marker that has been implicated in colorectal cancer. This protein has been shown to also be a docking protein or receptor for Bacillus anthracis toxin, the causative agent of the disease, anthrax. The binding of the protective antigen (PA) component, of the tripartite anthrax toxin, to this receptor protein mediates delivery of toxin components to the cytosol of cells. Once inside the cell, the other two components of anthrax toxin, edema factor (EF) and lethal factor (LF) disrupt normal cellular processes. Three alternatively spliced variants have been described.
Alias Symbols: ATR, FLJ10601, FLJ11298, FLJ21776, TEM8
Protein Interaction Partner: UBC, ELAVL1, Mad2l1, HDAC2, LRP6, BCL2L1,
Protein Size: 564

Poids moléculaire: 60 kDa

ID gène: 84168

NCBI Accession: NM_032208, NP_115584

UniProt: Q9H6X2