SENP6 anticorps (C-Term)

N° du produit ABIN2784245

Cet anticorps anti-SENP6 Polyclonal Lapin (ABIN2784245) détecte spécifiquement SENP6 dans WB. L’anticorps est réactif avec des échantillons de Humain, Boeuf (Vache), Cheval et Porc.

Aperçu rapide pour SENP6 anticorps (C-Term) (ABIN2784245)

Antigène: SENP6 (SUMO1/sentrin Specific Protease 6 (SENP6))

Reactivité: Humain, Boeuf (Vache), Cheval, Porc

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SENP6 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-SENP6 anticorps

Épitope: C-Term

Fonction: SENP6 Antibody - C-terminal region

Séquence: MNLANWFPPP RMRTKREEIR NIILKLQEDQ SKEKRKHKDT YSTEAPLGEG

Homologie: Cow: 79%, Horse: 79%, Human: 100%, Pig: 91%

Attributs du produit: This is a rabbit polyclonal antibody against SENP6. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the C terminal region of human SENP6

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP50600-100UG

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: prevent freeze-thaw cycles

Stock: 4 °C,-20 °C

Stockage commentaire: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Détails sur SENP6

Antigène: SENP6 (SUMO1/sentrin Specific Protease 6 (SENP6))

Autre désignation: SENP6

Sujet:

Background Information: SENP6 is a UBL-specific protease that deconjugates SUMO1, SUMO2 and SUMO3 from targeted proteins. It does not seem to be involved in the processing of full-length SUMO proteins to their mature forms. SENP6 deconjugates SUMO1 from RXRA, leading to transcriptional activation. It may act preferentially on substrates containing 3 or more SUMO2 or SUMO3 moieties.Ubiquitin-like molecules (UBLs), such as SUMO1 (UBL1, MIM 601912), are structurally related to ubiquitin (MIM 191339) and can be ligated to target proteins in a similar manner as ubiquitin. However, covalent attachment of UBLs does not result in degradation of the modified proteins. SUMO1 modification is implicated in the targeting of RANGAP1 (MIM 602362) to the nuclear pore complex, as well as in stabilization of I-kappa-B-alpha (NFKBIA, MIM 164008) from degradation by the 26S proteasome. Like ubiquitin, UBLs are synthesized as precursor proteins, with 1 or more amino acids following the C-terminal glycine-glycine residues of the mature UBL protein. Thus, the tail sequences of the UBL precursors need to be removed by UBL-specific proteases, such as SENP6, prior to their conjugation to target proteins (Kim et al., 2000 [PubMed 10799485]).[supplied by OMIM].

Gene Name: SUMO1/sentrin specific peptidase 6

Alternative Symbols: SSP1, SUSP1

Protein Name: Sentrin-specific protease 6

Poids moléculaire: 125kDa

ID gène: 26054

NCBI Accession: NP_001093879

UniProt: Q9GZR1