SENP6 anticorps (C-Term)

N° du produit ABIN2784245

Détail du produit anti-SENP6 anticorps

Antigène: SENP6 (SUMO1/sentrin Specific Protease 6 (SENP6))

Épitope: C-Term

Reactivité: Humain, Boeuf (Vache), Cheval, Porc

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SENP6 est non-conjugé

Application: Western Blotting (WB)

Séquence: MNLANWFPPP RMRTKREEIR NIILKLQEDQ SKEKRKHKDT YSTEAPLGEG

Homologie: Cow: 79%, Horse: 79%, Human: 100%, Pig: 91%

Attributs du produit: This is a rabbit polyclonal antibody against SENP6. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the C terminal region of human SENP6

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 1105 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur SENP6

Antigène: SENP6 (SUMO1/sentrin Specific Protease 6 (SENP6))

Autre désignation: SENP6 (SENP6 Produits)

Synonymes: anticorps SSP1, anticorps SUSP1, anticorps 2810017C20Rik, anticorps E130319N12Rik, anticorps Susp1, anticorps mKIAA0797, anticorps fc83h02, anticorps im:7148342, anticorps wu:fc83h02, anticorps zgc:171230, anticorps SUMO1/sentrin specific peptidase 6, anticorps SUMO/sentrin specific peptidase 6, anticorps SUMO1/sentrin specific peptidase 6a, anticorps SENP6, anticorps Senp6, anticorps senp6a

Sujet: SENP6 is a UBL-specific protease that deconjugates SUMO1, SUMO2 and SUMO3 from targeted proteins. It does not seem to be involved in the processing of full-length SUMO proteins to their mature forms. SENP6 deconjugates SUMO1 from RXRA, leading to transcriptional activation. It may act preferentially on substrates containing 3 or more SUMO2 or SUMO3 moieties.Ubiquitin-like molecules (UBLs), such as SUMO1 (UBL1, MIM 601912), are structurally related to ubiquitin (MIM 191339) and can be ligated to target proteins in a similar manner as ubiquitin. However, covalent attachment of UBLs does not result in degradation of the modified proteins. SUMO1 modification is implicated in the targeting of RANGAP1 (MIM 602362) to the nuclear pore complex, as well as in stabilization of I-kappa-B-alpha (NFKBIA, MIM 164008) from degradation by the 26S proteasome. Like ubiquitin, UBLs are synthesized as precursor proteins, with 1 or more amino acids following the C-terminal glycine-glycine residues of the mature UBL protein. Thus, the tail sequences of the UBL precursors need to be removed by UBL-specific proteases, such as SENP6, prior to their conjugation to target proteins (Kim et al., 2000 [PubMed 10799485]).[supplied by OMIM].
Alias Symbols: FLJ11355, FLJ11887, KIAA0389, KIAA0797, SSP1, SUSP1
Protein Interaction Partner: UBC, SP1, LMNA, COPS5, SUMO2, KAT5, SUMO1, PLA2G2A, RUVBL2, ARNT,
Protein Size: 1105

Poids moléculaire: 125 kDa

ID gène: 26054

NCBI Accession: NM_001100409, NP_001093879

UniProt: Q9GZR1