PYHIN1 anticorps (N-Term)

N° du produit ABIN2784367

Détail du produit anti-PYHIN1 anticorps

Antigène: PYHIN1 (Pyrin and HIN Domain Family, Member 1 (PYHIN1))

Épitope: N-Term

Reactivité: Humain, Souris, Boeuf (Vache), Chien, Rat, Cheval, Porc, Lapin

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PYHIN1 est non-conjugé

Application: Western Blotting (WB)

Séquence: ANNYKKIVLL KGLEVINDYH FRIVKSLLSN DLKLNPKMKE EYDKIQIADL

Homologie: Cow: 91%, Dog: 91%, Horse: 91%, Human: 100%, Mouse: 100%, Pig: 85%, Rabbit: 93%, Rat: 85%

Attributs du produit: This is a rabbit polyclonal antibody against PYHIN1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human PYHIN1

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 492 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur PYHIN1

Antigène: PYHIN1 (Pyrin and HIN Domain Family, Member 1 (PYHIN1))

Autre désignation: PYHIN1 (PYHIN1 Produits)

Synonymes: anticorps IFIX, anticorps RP11-520H16.1, anticorps 4930422C14, anticorps AI447904, anticorps Ifi209, anticorps Ifix, anticorps pyrin and HIN domain family member 1, anticorps interferon activated gene 209, anticorps PYHIN1, anticorps Ifi209

Sujet: PYHIN1 belongs to the HIN-200 family. This protein is major mediator of the tumor suppressor activity of IFN in breast cancer cells. It promotes ubiquitination and subsequent degradation of MDM2, which leads to p53/TP53 stabilization, and HDAC1, which in turn enhances maspin expression, and impairs invasive activity of cancer cells.
Alias Symbols: IFIX, MGC23885, RP11-520H16.1
Protein Interaction Partner: MDM2,
Protein Size: 492

Poids moléculaire: 55 kDa

ID gène: 149628

NCBI Accession: NM_152501, NP_689714

UniProt: Q6K0P9