Gephyrin anticorps (N-Term)

N° du produit ABIN2784653

Cet anticorps Lapin Polyclonal détecte spécifiquement Gephyrin dans WB. Il présente une réactivité envers Humain, Souris, Rat, Poisson zèbre (Danio rerio), Boeuf (Vache), Chien, Cobaye, Cheval et Lapin.

Aperçu rapide pour Gephyrin anticorps (N-Term) (ABIN2784653)

Antigène: Gephyrin (GPHN)

Reactivité: Humain, Souris, Rat, Poisson zèbre (Danio rerio), Boeuf (Vache), Chien, Cobaye, Cheval, Lapin

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Gephyrin est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-Gephyrin anticorps

Épitope: N-Term

Séquence: HDELEDLPSP PPPLSPPPTT SPHKQTEDKG VQCEEEEEEK KDSGVASTED

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%

Attributs du produit: This is a rabbit polyclonal antibody against GPHN. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human GPHN

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 736 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur Gephyrin

Antigène: Gephyrin (GPHN)

Autre désignation: GPHN

Sujet: GPHN is a neuronal assembly protein that anchors inhibitory neurotransmitter receptors to the postsynaptic cytoskeleton via high affinity binding to a receptor subunit domain and tubulin dimers. In nonneuronal tissues, the protein is also required for molybdenum cofactor biosynthesis. Mutations in this gene may be associated with the neurological condition hyperplexia and also lead to molybdenum cofactor deficiency. Numerous alternatively spliced transcript variants encoding different isoforms have been described, however, the full-length nature of all transcript variants is not currently known. This gene encodes a neuronal assembly protein that anchors inhibitory neurotransmitter receptors to the postsynaptic cytoskeleton via high affinity binding to a receptor subunit domain and tubulin dimers. In nonneuronal tissues, the encoded protein is also required for molybdenum cofactor biosynthesis. Mutations in this gene may be associated with the neurological condition hyperplexia and also lead to molybdenum cofactor deficiency. Numerous alternatively spliced transcript variants encoding different isoforms have been described, however, the full-length nature of all transcript variants is not currently known.
Alias Symbols: GEPH, GPH, GPHRYN, KIAA1385
Protein Interaction Partner: UBC, PAAF1, BRCC3, PPP4R1, ROCK2, MTA2, SPTAN1, SPATS1, KHDRBS1, GPHN, ACADVL, PCK1, Dynll1, OTUD4, PRPF4, ENAH, GLRB, DYNLL2, GABARAP, MTOR, PIN1, ARHGEF9, TUBA4A, PFN1,
Protein Size: 736

Poids moléculaire: 80 kDa

ID gène: 10243

NCBI Accession: NM_001024218, NP_001019389

UniProt: Q9NQX3

Pathways: Synaptic Membrane, Skeletal Muscle Fiber Development