COPA anticorps (N-Term)

N° du produit ABIN2784677

L’anticorps Lapin Polyclonal anti-COPA a été validé pour WB. Il convient pour détecter COPA dans des échantillons de Humain, Souris, Rat, Chien, Poisson zèbre (Danio rerio), Cheval, Cobaye, Lapin, Boeuf (Vache), Chévre et Saccharomyces cerevisiae. Il y a 2+ publications disponibles.

Aperçu rapide pour COPA anticorps (N-Term) (ABIN2784677)

Antigène: COPA (Coatomer Protein Complex, Subunit alpha (COPA))

Reactivité: Humain, Souris, Rat, Chien, Poisson zèbre (Danio rerio), Cheval, Cobaye, Lapin, Boeuf (Vache), Chévre, Saccharomyces cerevisiae

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp COPA est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-COPA anticorps

Épitope: N-Term

Séquence: PWILTSLHNG VIQLWDYRMC TLIDKFDEHD GPVRGIDFHK QQPLFVSGGD

Homologie: Cow: 100%, Dog: 100%, Goat: 86%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Yeast: 93%, Zebrafish: 100%

Attributs du produit: This is a rabbit polyclonal antibody against COPA. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human COPA

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 1224 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-COPA (ABIN2784677)

Li, Custer, Gilson, Hao, Beattie, Androphy: "α-COP binding to the survival motor neuron protein SMN is required for neuronal process outgrowth." dans: Human molecular genetics, Vol. 24, Issue 25, pp. 7295-307, (2015) (PubMed).

Ting, Wen, Liu, Hsieh-Li, Li, Lin-Chao: "The spinal muscular atrophy disease protein SMN is linked to the Golgi network." dans: PLoS ONE, Vol. 7, Issue 12, pp. e51826, (2013) (PubMed).

Détails sur COPA

Antigène: COPA (Coatomer Protein Complex, Subunit alpha (COPA))

Autre désignation: COPA

Sujet: In eukaryotic cells, protein transport between the endoplasmic reticulum and Golgi compartments is mediated in part by non-clathrin-coated vesicular coat proteins (COPs). Seven coat proteins have been identified, and they represent subunits of a complex known as coatomer. The subunits are designated alpha-COP, beta-COP, beta-prime-COP, gamma-COP, delta-COP, epsilon-COP, and zeta-COP. The alpha-COP, encoded by COPA, shares high sequence similarity with RET1P, the alpha subunit of the coatomer complex in yeast. Also, the N-terminal 25 amino acids of alpha-COP encode the bioactive peptide, xenin, which stimulates exocrine pancreatic secretion and may act as a gastrointestinal hormone.In eukaryotic cells, protein transport between the endoplasmic reticulum and Golgi compartments is mediated in part by non-clathrin-coated vesicular coat proteins (COPs). Seven coat proteins have been identified, and they represent subunits of a complex known as coatomer. The subunits are designated alpha-COP, beta-COP, beta-prime-COP, gamma-COP, delta-COP, epsilon-COP, and zeta-COP. The alpha-COP, encoded by COPA, shares high sequence similarity with RET1P, the alpha subunit of the coatomer complex in yeast. Also, the N-terminal 25 amino acids of alpha-COP encode the bioactive peptide, xenin, which stimulates exocrine pancreatic secretion and may act as a gastrointestinal hormone. Alternative splicing results in multiple splice forms encoding distinct isoforms.
Alias Symbols: FLJ26320, HEP-COP
Protein Interaction Partner: UBC, SUMO2, SMN1, STAU1, NUDCD1, SUMO1, NEDD8, RPA3, RPA2, RPA1, SUZ12, RNF2, COPZ1, DHX38, COPB2, CCT3, TCP1, SEPT2, ARCN1, UBD, VCAM1, ITGA4, COPB1, COPG2, COPG1, COPE, SEPT9, SEC23A, SEC24C, UBXN6, FBXO6, LMAN1, SACM1L, DDX20, TMED10, GEMIN2, COPA, CDK
Protein Size: 1224

Poids moléculaire: 135 kDa

ID gène: 1314

NCBI Accession: NM_004371, NP_004362

UniProt: P53621

Pathways: Hormone Activity