CENPB anticorps (C-Term)

N° du produit ABIN2784717

Cet anticorps anti-CENPB est un anticorps Lapin Polyclonal détectant CENPB dans WB. Adapté pour Humain, Souris, Rat, Cheval, Porc, Mouton, Boeuf (Vache), Saccharomyces cerevisiae et Poisson zèbre (Danio rerio).

Aperçu rapide pour CENPB anticorps (C-Term) (ABIN2784717)

Antigène: CENPB (Centromere Protein B (CENPB))

Reactivité: Humain, Souris, Rat, Cheval, Porc, Mouton, Boeuf (Vache), Saccharomyces cerevisiae, Poisson zèbre (Danio rerio)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CENPB est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-CENPB anticorps

Épitope: C-Term

Séquence: GGEDSDSDSE EEDDEEEDDE DEDDDDDEED GDEVPVPSFG EAMAYFAMVK

Homologie: Cow: 83%, Horse: 86%, Human: 100%, Mouse: 93%, Pig: 86%, Rat: 100%, Sheep: 86%, Yeast: 100%, Zebrafish: 75%

Attributs du produit: This is a rabbit polyclonal antibody against CENPB. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the C terminal region of human CENPB

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 599 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur CENPB

Antigène: CENPB (Centromere Protein B (CENPB))

Autre désignation: CENPB

Sujet: CENPB is a highly conserved protein that facilitates centromere formation. It is a DNA-binding protein that is derived from transposases of the pogo DNA transposon family. It contains a helix-loop-helix DNA binding motif at the N-terminus, and a dimerization domain at the C-terminus. This protein is proposed to play an important role in the assembly of specific centromere structures in interphase nuclei and on mitotic chromosomes. It is also considered a major centromere autoantigen recognized by sera from patients with anti-centromere antibodies.This gene product is a highly conserved protein that facilitates centromere formation. It is a DNA-binding protein that is derived from transposases of the pogo DNA transposon family. It contains a helix-loop-helix DNA binding motif at the N-terminus, and a dimerization domain at the C-terminus. The DNA binding domain recognizes and binds a 17-bp sequence (CENP-B box) in the centromeric alpha satellite DNA. This protein is proposed to play an important role in the assembly of specific centromere structures in interphase nuclei and on mitotic chromosomes. It is also considered a major centromere autoantigen recognized by sera from patients with anti-centromere antibodies. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: -
Protein Interaction Partner: UBC, RNF2, NR3C1, FBXO25, CENPA, APP, GFI1B, SUMO2, SMN1, PIN1, GSK3B, GADD45A, CSNK2B, CDKN1A, ANXA7, RPS6KA6, TK1, TAC1, TAF1D, PARP1, PARP2, HAND2, CENPB,
Protein Size: 599

Poids moléculaire: 65 kDa

ID gène: 1059

NCBI Accession: NM_001810, NP_001801

UniProt: P07199