CLK1 anticorps (N-Term)

N° du produit ABIN2784736

Cet anticorps anti-CLK1 est un anticorps Lapin Polyclonal détectant CLK1 dans WB. Adapté pour Humain, Souris, Boeuf (Vache), Chien, Cobaye, Cheval, Lapin et Rat. Ce Primary Antibody a été cité dans 2+ publications.

Aperçu rapide pour CLK1 anticorps (N-Term) (ABIN2784736)

Antigène: CLK1 (CDC like Kinase 1 (CLK1))

Reactivité: Humain, Souris, Boeuf (Vache), Chien, Cobaye, Cheval, Lapin, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CLK1 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-CLK1 anticorps

Épitope: N-Term

Séquence: HSSAQENKRC KYNHSKMCDS HYLESRSINE KDYHSRRYID EYRNDYTQGC

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 86%, Rabbit: 100%, Rat: 85%

Attributs du produit: This is a rabbit polyclonal antibody against CLK1. It was validated on Western Blot.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human CLK1

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 484 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-CLK1 (ABIN2784736)

Aubol, Wu, Keshwani, Movassat, Fattet, Hertel, Fu, Adams: "Release of SR Proteins from CLK1 by SRPK1: A Symbiotic Kinase System for Phosphorylation Control of Pre-mRNA Splicing." dans: Molecular cell, Vol. 63, Issue 2, pp. 218-228, (2016) (PubMed).

Eisenreich, Zakrzewicz, Huber, Thierbach, Pepke, Goldin-Lang, Schultheiss, Pries, Rauch: "Regulation of pro-angiogenic tissue factor expression in hypoxia-induced human lung cancer cells." dans: Oncology reports, Vol. 30, Issue 1, pp. 462-70, (2013) (PubMed).

Détails sur CLK1

Antigène: CLK1 (CDC like Kinase 1 (CLK1))

Autre désignation: CLK1

Sujet: This gene encodes a member of the CDC2-like (or LAMMER) family of dual specificity protein kinases. In the nucleus, the encoded protein phosphorylates serine/arginine-rich proteins involved in pre-mRNA processing, releasing them into the nucleoplasm. The choice of splice sites during pre-mRNA processing may be regulated by the concentration of transacting factors, including serine/arginine rich proteins. Therefore, the encoded protein may play an indirect role in governing splice site selection. Multiple transcript variants encoding different isoforms have been found for this gene.
Alias Symbols: CLK, CLK/STY, STY
Protein Interaction Partner: KRTAP10-7, PDE9A, PRMT5, SRPK2, SRPK1, CLK1, BAG3, PIAS4, ISG15, UBC, YWHAG, LUC7L3, PPIG, SRSF6, PRPF4, GOLM1, UBL5, SRSF1, PTPN1, MBP, BCLAF1, NCOR1, SRSF3, SAFB,
Protein Size: 484

Poids moléculaire: 57 kDa

ID gène: 1195

NCBI Accession: NM_004071, NP_004062

UniProt: P49759