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CLK1 anticorps (N-Term)

CLK1 Reactivité: Humain, Souris, Cheval, Lapin, Rat, Boeuf (Vache), Chien, Cobaye WB Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN2784736
  • Antigène Voir toutes CLK1 Anticorps
    CLK1 (CDC like Kinase 1 (CLK1))
    Épitope
    • 14
    • 9
    • 7
    • 5
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reactivité
    • 33
    • 27
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain, Souris, Cheval, Lapin, Rat, Boeuf (Vache), Chien, Cobaye
    Hôte
    • 45
    • 2
    Lapin
    Clonalité
    • 47
    Polyclonal
    Conjugué
    • 20
    • 5
    • 4
    • 4
    • 4
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp CLK1 est non-conjugé
    Application
    • 39
    • 29
    • 9
    • 7
    • 2
    • 2
    • 1
    Western Blotting (WB)
    Séquence
    HSSAQENKRC KYNHSKMCDS HYLESRSINE KDYHSRRYID EYRNDYTQGC
    Homologie
    Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 86%, Rabbit: 100%, Rat: 85%
    Attributs du produit
    This is a rabbit polyclonal antibody against CLK1. It was validated on Western Blot.
    Purification
    Affinity Purified
    Immunogène
    The immunogen is a synthetic peptide directed towards the N terminal region of human CLK1
    Top Product
    Discover our top product CLK1 Anticorps primaire
  • Indications d'application
    Optimal working dilutions should be determined experimentally by the investigator.
    Commentaires

    Antigen size: 484 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid repeated freeze-thaw cycles.
    Stock
    -20 °C
    Stockage commentaire
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Aubol, Wu, Keshwani, Movassat, Fattet, Hertel, Fu, Adams: "Release of SR Proteins from CLK1 by SRPK1: A Symbiotic Kinase System for Phosphorylation Control of Pre-mRNA Splicing." dans: Molecular cell, Vol. 63, Issue 2, pp. 218-228, (2016) (PubMed).

    Eisenreich, Zakrzewicz, Huber, Thierbach, Pepke, Goldin-Lang, Schultheiss, Pries, Rauch: "Regulation of pro-angiogenic tissue factor expression in hypoxia-induced human lung cancer cells." dans: Oncology reports, Vol. 30, Issue 1, pp. 462-70, (2013) (PubMed).

  • Antigène
    CLK1 (CDC like Kinase 1 (CLK1))
    Autre désignation
    CLK1 (CLK1 Produits)
    Synonymes
    anticorps CLK, anticorps CLK/STY, anticorps STY, anticorps CDC like kinase 1, anticorps CDC-like kinase 1, anticorps CLK1, anticorps Clk1
    Sujet
    This gene encodes a member of the CDC2-like (or LAMMER) family of dual specificity protein kinases. In the nucleus, the encoded protein phosphorylates serine/arginine-rich proteins involved in pre-mRNA processing, releasing them into the nucleoplasm. The choice of splice sites during pre-mRNA processing may be regulated by the concentration of transacting factors, including serine/arginine rich proteins. Therefore, the encoded protein may play an indirect role in governing splice site selection. Multiple transcript variants encoding different isoforms have been found for this gene.
    Alias Symbols: CLK, CLK/STY, STY
    Protein Interaction Partner: KRTAP10-7, PDE9A, PRMT5, SRPK2, SRPK1, CLK1, BAG3, PIAS4, ISG15, UBC, YWHAG, LUC7L3, PPIG, SRSF6, PRPF4, GOLM1, UBL5, SRSF1, PTPN1, MBP, BCLAF1, NCOR1, SRSF3, SAFB,
    Protein Size: 484
    Poids moléculaire
    57 kDa
    ID gène
    1195
    NCBI Accession
    NM_004071, NP_004062
    UniProt
    P49759
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