HAX1 anticorps (Middle Region)

N° du produit ABIN2784795

Cet anticorps anti-HAX1 est un anticorps Lapin Polyclonal détectant HAX1 dans WB et IHC. Adapté pour Humain, Souris, Rat, Cobaye, Cheval, Boeuf (Vache) et Chien.

Aperçu rapide pour HAX1 anticorps (Middle Region) (ABIN2784795)

Antigène: HAX1 (HCLS1 Associated Protein X-1 (HAX1))

Reactivité: Humain, Souris, Rat, Cobaye, Cheval, Boeuf (Vache), Chien

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp HAX1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Détail du produit anti-HAX1 anticorps

Épitope: Middle Region

Séquence: LPGPESETPG ERLREGQTLR DSMLKYPDSH QPRIFGGVLE SDARSESPQP

Homologie: Cow: 86%, Dog: 93%, Guinea Pig: 100%, Horse: 85%, Human: 100%, Mouse: 100%, Rat: 93%

Attributs du produit: This is a rabbit polyclonal antibody against HAX1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human HAX1

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 279 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur HAX1

Antigène: HAX1 (HCLS1 Associated Protein X-1 (HAX1))

Autre désignation: HAX1

Sujet: HAX1 is known to associate with hematopoietic cell-specific Lyn substrate 1, a substrate of Src family tyrosine kinases. It also interacts with the product of the polycystic kidney disease 2 gene, mutations in which are associated with autosomal-dominant polycystic kidney disease, and with the F-actin-binding protein, cortactin. It was earlier thought that this gene product is mainly localized in the mitochondria, however, recent studies indicate it to be localized in the cell body. Mutations in this gene result in autosomal recessive severe congenital neutropenia, also known as Kostmann disease.The protein encoded by this gene is known to associate with hematopoietic cell-specific Lyn substrate 1, a substrate of Src family tyrosine kinases. It also interacts with the product of the polycystic kidney disease 2 gene, mutations in which are associated with autosomal-dominant polycystic kidney disease, and with the F-actin-binding protein, cortactin. It was earlier thought that this gene product is mainly localized in the mitochondria, however, recent studies indicate it to be localized in the cell body. Mutations in this gene result in autosomal recessive severe congenital neutropenia, also known as Kostmann disease. Two transcript variants encoding different isoforms have been found for this gene.
Alias Symbols: HCLSBP1, HS1BP1, SCN3
Protein Interaction Partner: ERLIN2, UBC, BIRC3, CEP250, TUBGCP2, TUBGCP3, MAPK10, HIPK1, DYRK4, ZNF420, POLR1D, ZNRD1, RBX1, STAT5B, RPA1, PPP3CC, CFTR, EWSR1, SHC1, HTRA2, NEDD4L, CUL3, CUL4A, PIDD1, SVIL, EBNA-LP, AMFR, HNF4G, AKAP10, TUBB4A, ABCC4, MATN4, EIF3D, RGS1, HSP90AB1, H
Protein Size: 279

Poids moléculaire: 31 kDa

ID gène: 10456

NCBI Accession: NM_006118, NP_006109

UniProt: O00165

Pathways: Regulation of Actin Filament Polymerization