EGLN3 anticorps (C-Term)

N° du produit ABIN2784911

Cet anticorps Lapin Polyclonal détecte spécifiquement EGLN3 dans WB. Il présente une réactivité avec des échantillons de Humain, Souris, Rat, Boeuf (Vache), Chien, Cheval, Lapin, Cobaye, Mouton et Poisson zèbre (Danio rerio).

Aperçu rapide pour EGLN3 anticorps (C-Term) (ABIN2784911)

Antigène: EGLN3 (Egl-9 Family Hypoxia Inducible Factor 3 (EGLN3))

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Chien, Cheval, Lapin, Cobaye, Mouton, Poisson zèbre (Danio rerio)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp EGLN3 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-EGLN3 anticorps

Épitope: C-Term

Fonction: EGLN3 Antibody - C-terminal region

Séquence: FWSDRRNPHE VQPSYATRYA MTVWYFDAEE RAEAKKKFRN LTRKTESALT

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Sheep: 77%, Zebrafish: 75%

Attributs du produit: This is a rabbit polyclonal antibody against EGLN3. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the C terminal region of human EGLN3

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP52402-100UG

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: prevent freeze-thaw cycles

Stock: 4 °C,-20 °C

Stockage commentaire: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Détails sur EGLN3

Antigène: EGLN3 (Egl-9 Family Hypoxia Inducible Factor 3 (EGLN3))

Autre désignation: EGLN3

Sujet:

Background Information: EGLN3 catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. It hydroxylates HIF-1 alpha at 'Pro-564', and HIF-2 alpha. EGLN3 functions as a cellular oxygen sensor and, under normoxic conditions, targets HIF through the hydroxylation for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. It may play a role in cell growth regulation in muscle cells and in apoptosis in neuronal tissue. EGLN3 promotes cell death through a caspase-dependent mechanism.

Gene Name: Egl nine homolog 3 (C. elegans)

Alternative Symbols: PHD3, HIFPH3, HIFP4H3

Protein Name: Egl nine homolog 3

Poids moléculaire: 27kDa

ID gène: 112399

NCBI Accession: NP_071356

UniProt: Q9H6Z9

Pathways: Positive Regulation of Endopeptidase Activity