CAPN10 anticorps (N-Term)

N° du produit ABIN2784913

Détail du produit anti-CAPN10 anticorps

Antigène: CAPN10 (Calpain 10 (CAPN10))

Épitope: N-Term

Reactivité: Humain, Souris, Lapin, Chien, Rat, Cobaye, Boeuf (Vache)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CAPN10 est non-conjugé

Application: Western Blotting (WB)

Séquence: MRAGRGATPA RELFRDAAFP AADSSLFCDL STPLAQFRED ITWRRPQEIC

Homologie: Cow: 92%, Dog: 100%, Guinea Pig: 93%, Human: 100%, Mouse: 93%, Rabbit: 100%, Rat: 93%

Attributs du produit: This is a rabbit polyclonal antibody against CAPN10. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human CAPN10

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 517 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur CAPN10

Antigène: CAPN10 (Calpain 10 (CAPN10))

Autre désignation: CAPN10 (CAPN10 Produits)

Sujet: CAPN10 is the calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction.Calpains are ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large catalytic subunit has four domains: domain I, the N-terminal regulatory domain that is processed upon calpain activation, domain II, the protease domain, domain III, a linker domain of unknown function, and domain IV, the calmodulin-like calcium-binding domain. This gene encodes a large subunit. It is an atypical calpain in that it lacks the calmodulin-like calcium-binding domain and instead has a divergent C-terminal domain. It is similar in organization to calpains 5 and 6. This gene is associated with type 2 or non-insulin-dependent diabetes mellitus (NIDDM) and located within the NIDDM1 region. Multiple alternative transcript variants encoding different isoforms have been described for this gene.
Alias Symbols: CANP10, NIDDM1
Protein Interaction Partner: EFNB1, FLOT1, PSMA7, FANCC,
Protein Size: 517

Poids moléculaire: 58 kDa

ID gène: 11132

NCBI Accession: NM_023085, NP_075573

UniProt: Q9HC96

Pathways: Positive Regulation of Peptide Hormone Secretion