ADC anticorps (C-Term)

N° du produit ABIN2784945

L’anticorps anti-ADC Polyclonal Lapin est utilisé pour la détection de ADC dans des échantillons de Humain, Souris, Rat, Chien, Cobaye, Lapin, Boeuf (Vache), Cheval, Mouton et Saccharomyces cerevisiae. Il a été validé pour WB.

Aperçu rapide pour ADC anticorps (C-Term) (ABIN2784945)

Antigène: ADC (Arginine Decarboxylase (ADC))

Reactivité: Humain, Souris, Rat, Chien, Cobaye, Lapin, Boeuf (Vache), Cheval, Mouton, Saccharomyces cerevisiae

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ADC est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-ADC anticorps

Épitope: C-Term

Fonction: AZIN2 Antibody - C-terminal region

Séquence: AELGRYYVTS AFTVAVSIIA KKEVLLDQPG REEENGSTSK TIVYHLDEGV

Homologie: Cow: 92%, Dog: 100%, Guinea Pig: 100%, Horse: 92%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Sheep: 85%, Yeast: 77%

Attributs du produit: This is a rabbit polyclonal antibody against ADC. It was validated on Western Blot.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the C-terminal region of Human ADC

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP52477-100UG

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: prevent freeze-thaw cycles

Stock: 4 °C,-20 °C

Stockage commentaire: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Détails sur ADC

Antigène: ADC (Arginine Decarboxylase (ADC))

Autre désignation: AZIN2

Sujet:

Background Information: The protein encoded by this gene belongs to the antizyme inhibitor family, which plays a role in cell growth and proliferation by maintaining polyamine homeostasis within the cell. Antizyme inhibitors are homologs of ornithine decarboxylase (ODC, the key enzyme in polyamine biosynthesis) that have lost the ability to decarboxylase ornithine; however, retain the ability to bind to antizymes. Antizymes negatively regulate intracellular polyamine levels by binding to ODC and targeting it for degradation, as well as by inhibiting polyamine uptake. Antizyme inhibitors function as positive regulators of polyamine levels by sequestering antizymes and neutralizing their effect. This gene encodes antizyme inhibitor 2, the second member of this gene family. Like antizyme inhibitor 1, antizyme inhibitor 2 interacts with all 3 antizymes and stimulates ODC activity and polyamine uptake. However, unlike antizyme inhibitor 1, which is ubiquitously expressed and localized in the nucleus and cytoplasm, antizyme inhibitor 2 is predominantly expressed in the brain and testis and localized in the endoplasmic reticulum-golgi intermediate compartment. Recent studies indicate that antizyme inhibitor 2 is also expressed in specific cell types in ovaries, adrenal glands and pancreas, and in mast cells. The exact function of this gene is not known, however, available data suggest its role in cell growth, spermiogenesis, vesicular trafficking and secretion. Accumulation of antizyme inhibitor 2 has also been observed in brains of patients with Alzheimer's disease. There has been confusion in literature and databases over the nomenclature of this gene, stemming from an earlier report that a human cDNA clone (identical to ODCp/AZIN2) had arginine decarboxylase (ADC) activity (PMID:14738999). Subsequent studies in human and mouse showed that antizyme inhibitor 2 was devoid of arginine decarboxylase activity (PMID:19956990). Alternatively spliced transcript variants have been described for this gene.

Gene Name: antizyme inhibitor 2

Alternative Symbols: ADC, AZI2, ODCp, AZIB1, ODC-p, ODC1L

Protein Name: antizyme inhibitor 2

Poids moléculaire: 41kDa

ID gène: 113451

NCBI Accession: NP_443724

UniProt: Q96A70