MTPN anticorps (Middle Region)

N° du produit ABIN2785128

Détail du produit anti-MTPN anticorps

Antigène: MTPN (Myotrophin (MTPN))

Épitope: Middle Region

Reactivité: Humain, Souris, Rat, Chien, Boeuf (Vache), Lapin, Cobaye, Poisson zèbre (Danio rerio), Cheval

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MTPN est non-conjugé

Application: Western Blotting (WB)

Séquence: GRKPLHYAAD CGQLEILEFL LLKGADINAP DKHHITPLLS AVYEGHVSCV

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 86%

Attributs du produit: This is a rabbit polyclonal antibody against MTPN. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human MTPN

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 118 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-MTPN (ABIN2785128)

Nghiem, Hoffman, Mittal, Brown, Schatzberg, Ghimbovschi, Wang, Kornegay: "Sparing of the dystrophin-deficient cranial sartorius muscle is associated with classical and novel hypertrophy pathways in GRMD dogs." dans: The American journal of pathology, Vol. 183, Issue 5, pp. 1411-24, (2013) (PubMed).

Détails sur MTPN

Antigène: MTPN (Myotrophin (MTPN))

Autre désignation: MTPN (MTPN Produits)

Synonymes: anticorps MGC76285, anticorps GCDP, anticorps V-1, anticorps Gcdp, anticorps wu:fa10f07, anticorps zgc:64078, anticorps 5033418D15Rik, anticorps V1, anticorps myotrophin, anticorps myotrophin S homeolog, anticorps mtpn, anticorps MTPN, anticorps Mtpn, anticorps mtpn.S

Sujet: MTPN has a potential role in cerebellar morphogenesis. MTPN may function in differentiation of cerebellar neurons, particularly of granule cells. MTPN seems to be associated with cardiac hypertrophy.The transcript produced from this gene is bi-cistronic and can encode both myotrophin and leucine zipper protein 6. The myotrophin protein is associated with cardiac hypertrophy, where it is involved in the conversion of NFkappa B p50-p65 heterodimers to p50-p50 and p65-p65 homodimers. This protein also has a potential function in cerebellar morphogenesis, and it may be involved in the differentiation of cerebellar neurons, particularly of granule cells. A cryptic ORF at the 3' end of this transcript uses a novel internal ribosome entry site and a non-AUG translation initiation codon to produce leucine zipper protein 6, a 6.4 kDa tumor antigen that is associated with myeloproliferative disease.
Alias Symbols: FLJ31098, GCDP, V-1
Protein Interaction Partner: RBBP4, RAB1A, PTPN11, OXCT1, MTAP, PDIA3, ATP6V1A, UBC, NPLOC4, ELAVL1, MAPK1, CAPZB, RELA, NFKB1, REL, DSTYK,
Protein Size: 118

Poids moléculaire: 13 kDa

ID gène: 136319

NCBI Accession: NM_145808, NP_665807

UniProt: P58546