H1FOO anticorps (N-Term)

N° du produit ABIN2785287

Détail du produit anti-H1FOO anticorps

Antigène: H1FOO (H1 Histone Family, Member O, Oocyte-Specific (H1FOO))

Épitope: N-Term

Reactivité: Humain, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp H1FOO est non-conjugé

Application: Western Blotting (WB)

Séquence: MAPGSVTSDI SPSSTSTAGS SRSPESEKPG PSHGGVPPGG PSHSSLPVGR

Homologie: Human: 100%, Rat: 83%

Attributs du produit: This is a rabbit polyclonal antibody against H1FOO. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human H1FOO

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 346 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-H1FOO (ABIN2785287)

Hongo, Noguchi, Okuyama, Tanaka, Nishino: "Repetitive interactions observed in the crystal structure of a collagen-model peptide, [(Pro-Pro-Gly)9]3." dans: Journal of biochemistry, Vol. 138, Issue 2, pp. 135-44, (2005) (PubMed).

Tanaka, Kihara, Hennebold, Eppig, Viveiros, Emery, Carrell, Kirkman, Meczekalski, Zhou, Bondy, Becker, Schultz, Misteli, De La Fuente, King, Adashi: "H1FOO is coupled to the initiation of oocytic growth." dans: Biology of reproduction, Vol. 72, Issue 1, pp. 135-42, (2004) (PubMed).

Détails sur H1FOO

Antigène: H1FOO (H1 Histone Family, Member O, Oocyte-Specific (H1FOO))

Autre désignation: H1FOO (H1FOO Produits)

Synonymes: anticorps osH1, anticorps C86609, anticorps H1fo, anticorps H1oo, anticorps b4, anticorps RGD1566236, anticorps H1 histone family member O oocyte specific, anticorps H1 histone family, member O, oocyte-specific, anticorps H1 histone family member O oocyte specific S homeolog, anticorps H1FOO, anticorps H1foo, anticorps h1foo.S

Sujet: H1FOO may play a key role in the control of gene expression during oogenesis and early embryogenesis, presumably through the perturbation of chromatin structure. H1FOO is essential for meiotic maturation of germinal vesicle-stage oocytes. The somatic type linker histone H1c is rapidly replaced by H1oo in a donor nucleus transplanted into an oocyte. The greater mobility of H1oo as compared to H1c may contribute to this rapid replacement and increased instability of the embryonic chromatin structure. The rapid replacement of H1c with H1oo may play an important role in nuclear remodeling.Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. The protein encoded is a member of the histone H1 family. This gene contains introns, unlike most histone genes. The protein encoded is a member of the histone H1 family. The related mouse gene is expressed only in oocytes.
Alias Symbols: MGC50807, osH1
Protein Size: 346

Poids moléculaire: 36 kDa

ID gène: 132243

NCBI Accession: NM_153833, NP_722575

UniProt: Q8IZA3