CHMP4B anticorps (Middle Region)

N° du produit ABIN2785348

Cet anticorps Lapin Polyclonal détecte spécifiquement CHMP4B dans WB. Il présente une réactivité envers Humain, Souris, Rat, Boeuf (Vache), Chien, Cobaye, Cheval, Lapin et Poisson zèbre (Danio rerio) et a été mentionné dans 1 publication.

Aperçu rapide pour CHMP4B anticorps (Middle Region) (ABIN2785348)

Antigène: CHMP4B (Charged Multivesicular Body Protein 4B (CHMP4B))

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Chien, Cobaye, Cheval, Lapin, Poisson zèbre (Danio rerio)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CHMP4B est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-CHMP4B anticorps

Épitope: Middle Region

Séquence: EEISTAISKP VGFGEEFDED ELMAELEELE QEELDKNLLE ISGPETVPLP

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%

Attributs du produit: This is a rabbit polyclonal antibody against CHMP4B. It was validated on Western Blot.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human CHMP4B

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 224 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-CHMP4B (ABIN2785348)

Bodon, Chassefeyre, Pernet-Gallay, Martinelli, Effantin, Hulsik, Belly, Goldberg, Chatellard-Causse, Blot, Schoehn, Weissenhorn, Sadoul: "Charged multivesicular body protein 2B (CHMP2B) of the endosomal sorting complex required for transport-III (ESCRT-III) polymerizes into helical structures deforming the plasma membrane." dans: The Journal of biological chemistry, Vol. 286, Issue 46, pp. 40276-86, (2011) (PubMed).

Détails sur CHMP4B

Antigène: CHMP4B (Charged Multivesicular Body Protein 4B (CHMP4B))

Autre désignation: CHMP4B

Sujet: This gene encodes a member of the chromatin-modifying protein/charged multivesicular body protein (CHMP) protein family. The protein is part of the endosomal sorting complex required for transport (ESCRT) complex III (ESCRT-III), which functions in the sorting of endocytosed cell-surface receptors into multivesicular endosomes. The ESCRT machinery also functions in the final abscisson stage of cytokinesis and in the budding of enveloped viruses such as HIV-1. The three proteins of the CHMP4 subfamily interact with programmed cell death 6 interacting protein (PDCD6IP, also known as ALIX), which also functions in the ESCRT pathway. The CHMP4 proteins assemble into membrane-attached 5-nm filaments that form circular scaffolds and promote or stabilize outward budding. These polymers are proposed to help generate the luminal vesicles of multivesicular bodies. Mutations in this gene result in autosomal dominant posterior polar cataracts.
Alias Symbols: C20orf178, CHMP4A, CTPP3, SNF7, SNF7-2, Shax1, dJ553F4.4, VPS32B, Vps32-2
Protein Interaction Partner: UBC, TP53, CHMP6, UBE2I, PDCD6IP, VCAM1, ITGA4, RPLP0P6, MVP, ATP6V1B1, BROX, CHMP4B, CHMP4C, CHMP1B, CHMP3, CHMP5, CHMP4A, HIPK2, VPS4A, STAMBP, PIAS2, EXOSC9, HCVgp1, NOLC1, PTPN23,
Protein Size: 224

Poids moléculaire: 25 kDa

ID gène: 128866

NCBI Accession: NM_176812, NP_789782

UniProt: Q9H444