Inhibin alpha anticorps (N-Term)

N° du produit ABIN2785468

Cet anticorps anti-Inhibin alpha est un anticorps Lapin Polyclonal détectant Inhibin alpha dans WB. Adapté pour Humain, Rat, Souris, Porc, Boeuf (Vache), Mouton, Lapin, Chien, Chévre, Cheval et Saccharomyces cerevisiae.

Aperçu rapide pour Inhibin alpha anticorps (N-Term) (ABIN2785468)

Antigène: Inhibin alpha (INHA) (Inhibin, alpha (INHA))

Reactivité: Humain, Rat, Souris, Porc, Boeuf (Vache), Mouton, Lapin, Chien, Chévre, Cheval, Saccharomyces cerevisiae

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Inhibin alpha est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-Inhibin alpha anticorps

Épitope: N-Term

Séquence: GLAQEAEEGL FRYMFRPSQH TRSRQVTSAQ LWFHTGLDRQ GTAASNSSEP

Homologie: Cow: 100%, Dog: 86%, Goat: 100%, Horse: 93%, Human: 100%, Mouse: 86%, Pig: 100%, Rabbit: 79%, Rat: 93%, Sheep: 100%, Yeast: 79%

Attributs du produit: This is a rabbit polyclonal antibody against INHA. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human INHA

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 366 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur Inhibin alpha

Antigène: Inhibin alpha (INHA) (Inhibin, alpha (INHA))

Autre désignation: INHA

Sujet: INHA joins either the beta A or beta B subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumour-suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore be used as a marker for primary as well as recurrent disease. However, in prostate cancer, expression of the inhibin alpha-subunit gene was suppressed and was not detectable in poorly differentiated tumor cells. Furthermore, because expression in gonadal and various extragonadal tissues may vary severalfold in a tissue-specific fashion, it is proposed that inhibin may be both a growth/differentiation factor and a hormone. The inhibin alpha subunit joins either the beta A or beta B subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumour-suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore be used as a marker for primary as well as recurrent disease. However, in prostate cancer, expression of the inhibin alpha-subunit gene was suppressed and was not detectable in poorly differentiated tumor cells. Furthermore, because expression in gonadal and various extragonadal tissues may vary severalfold in a tissue-specific fashion, it is proposed that inhibin may be both a growth/differentiation factor and a hormone. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: -
Protein Interaction Partner: SIAH1, TGFBR3, INHBB, INHBA, FST, ACVR2A,
Protein Size: 366

Poids moléculaire: 40 kDa

ID gène: 3623

NCBI Accession: NM_002191, NP_002182

UniProt: P05111

Pathways: Peptide Hormone Metabolism, Hormone Activity, Negative Regulation of Hormone Secretion