MLF1 anticorps (N-Term)

N° du produit ABIN2785560

Cet anticorps Lapin Polyclonal détecte spécifiquement MLF1 dans WB. Il présente une réactivité avec des échantillons de Humain, Souris, Rat et Lapin.Il a été cité dans 1 publication.

Aperçu rapide pour MLF1 anticorps (N-Term) (ABIN2785560)

Antigène: MLF1 (Myeloid Leukemia Factor 1 (MLF1))

Reactivité: Humain, Souris, Rat, Lapin

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MLF1 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-MLF1 anticorps

Épitope: N-Term

Fonction: MLF1 Antibody - N-terminal region

Séquence: GRDLLSISDG RGRAHNRRGH NDGEDSLTHT DVSSFQTMDQ MVSNMRNYMQ

Homologie: Human: 100%, Mouse: 79%, Rabbit: 90%, Rat: 79%

Attributs du produit: This is a rabbit polyclonal antibody against MLF1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human MLF1

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under ABIN8105926

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: prevent freeze-thaw cycles

Stock: 4 °C,-20 °C

Stockage commentaire: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-MLF1 (ABIN2785560)

Li, Wu, Jiang, Liu, Wu, Inagaki, Izawa, Mizisin, Engvall, Shelton: "Non-pathogenic protein aggregates in skeletal muscle in MLF1 transgenic mice." dans: Journal of the neurological sciences, Vol. 264, Issue 1-2, pp. 77-86, (2007) (PubMed).

Détails sur MLF1

Antigène: MLF1 (Myeloid Leukemia Factor 1 (MLF1))

Autre désignation: MLF1

Sujet:

Background Information: MLF1 is involved in lineage commitment of primary hemopoietic progenitors by restricting erythroid formation and enhancing myeloid formation. It interferes with erythopoietin-induced erythroid terminal differentiation by preventing cells from exiting the cell cycle through suppression of CDKN1B/p27Kip1 levels. MLF1 suppresses RFWD2/COP1 activity via CSN3 which activates p53 and induces cell cycle arrest.It binds DNA and affects the expression of a number of genes so may function as a transcription factor in the nucleus.

Gene Name: Myeloid leukemia factor 1

Alternative Symbols: -

Protein Name: Myeloid leukemia factor 1

Poids moléculaire: 29kDa

ID gène: 4291

NCBI Accession: NP_071888

UniProt: P58340