Granulin anticorps (Middle Region)

N° du produit ABIN2785816

Cet anticorps Lapin Polyclonal détecte spécifiquement Granulin dans WB et IHC. Il présente une réactivité envers Humain, Cheval, Boeuf (Vache), Chien et Lapin.

Aperçu rapide pour Granulin anticorps (Middle Region) (ABIN2785816)

Antigène: Granulin (GRN)

Reactivité: Humain, Cheval, Boeuf (Vache), Chien, Lapin

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Granulin est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Détail du produit anti-Granulin anticorps

Épitope: Middle Region

Séquence: CPMPNATCCS DHLHCCPQDT VCDLIQSKCL SKENATTDLL TKLPAHTVGD

Homologie: Cow: 92%, Dog: 92%, Horse: 92%, Human: 100%, Rabbit: 85%

Attributs du produit: This is a rabbit polyclonal antibody against GRN. It was validated on Western Blot.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of Human GRN

Information d'application

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeat freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur Granulin

Antigène: Granulin (GRN)

Autre désignation: GRN

Sujet: Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88 kDa precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis.
Alias Symbols: CLN11, GEP, GP88, PCDGF, PEPI, PGRN
Protein Interaction Partner: OTX1, HOXA1, DLX2, SGTA, KRTAP26-1, KRTAP10-7, CCDC33, ARFGAP1, FANCL, NLK, GLRX3, EED, HECW2, Hk3, RPS6KA1, NPM1, POT1, FRAT1, YY1, TGM2, RAC1, PRKAB2, PIK3R2, SMAD9, KRT18, CRY1, CFTR, CCNG1, FBXO6, GFI1B, ATN1, CDK2, CRKL, VHL, SIRT3, ATXN7, CACNA1A, C
Protein Size: 438

Poids moléculaire: 48 kDa

ID gène: 2896

NCBI Accession: NM_002087, NP_002078