RPSA/Laminin Receptor anticorps (Middle Region)

N° du produit ABIN2785828

Détail du produit anti-RPSA/Laminin Receptor anticorps

Antigène: RPSA/Laminin Receptor (RPSA) (Ribosomal Protein SA (RPSA))

Épitope: Middle Region

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Mouton, Chévre, Cheval, Lapin, Chien, Poisson zèbre (Danio rerio), Cobaye

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RPSA/Laminin Receptor est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Séquence: TFTNQIQAAF REPRLLVVTD PRADHQPLTE ASYVNLPTIA LCNTDSPLRY

Homologie: Cow: 100%, Dog: 100%, Goat: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Sheep: 100%, Zebrafish: 100%

Attributs du produit: This is a rabbit polyclonal antibody against RPSA. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human RPSA

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 295 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur RPSA/Laminin Receptor

Antigène: RPSA/Laminin Receptor (RPSA) (Ribosomal Protein SA (RPSA))

Autre désignation: RPSA (RPSA Produits)

Synonymes: anticorps 37LRP, anticorps 67LR, anticorps LBP/p40, anticorps LRP/LR, anticorps LamR, anticorps rpsa, anticorps LamR1, anticorps RPSA, anticorps LAMBR, anticorps LAMR1, anticorps LBP, anticorps LRP, anticorps NEM/1CHD4, anticorps SA, anticorps lamR, anticorps p40, anticorps 67kDa, anticorps 67lr, anticorps AL022858, anticorps Lamr, anticorps Lamr1, anticorps Lamrl1, anticorps MLR, anticorps P40, anticorps P40-3, anticorps P40-8, anticorps lamr1, anticorps zgc:55831, anticorps zgc:77824, anticorps DMRT1, anticorps 40S ribosomal protein SA, anticorps 67kD laminin receptor, anticorps ribosomal protein SA, anticorps rssa, anticorps rpsa, anticorps RPSA, anticorps Rpsa, anticorps LOC100144340

Sujet: RPSA is required for the assembly and/or stability of the 40S ribosomal subunit. RPSA is also required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. RPSA plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. RPSA may play a role in cell fate determination and tissue morphogenesis. RPSA also acts as a receptor for several other ligands, including the pathogenic prion protein, viruses, and bacteria.Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Many of the effects of laminin are mediated through interactions with cell surface receptors. These receptors include members of the integrin family, as well as non-integrin laminin-binding proteins. This gene encodes a high-affinity, non-integrin family, laminin receptor 1. This receptor has been variously called 67 kD laminin receptor, 37 kD laminin receptor precursor (37LRP) and p40 ribosome-associated protein. The amino acid sequence of laminin receptor 1 is highly conserved through evolution, suggesting a key biological function. It has been observed that the level of the laminin receptor transcript is higher in colon carcinoma tissue and lung cancer cell line than their normal counterparts. Also, there is a correlation between the upregulation of this polypeptide in cancer cells and their invasive and metastatic phenotype. Multiple copies of this gene exist, however, most of them are pseudogenes thought to have arisen from retropositional events. Two alternatively spliced transcript variants encoding the same protein have been found for this gene.
Alias Symbols: 37LRP, 67LR, LAMBR, LAMR1, LRP, p40, SA, LBP, lamR, LRP/LR, LBP/p40, NEM/1CHD4
Protein Interaction Partner: UBC, SUMO2, MDM2, ZBTB1, RNF2, SUP35, rev, SYNCRIP, GNB2L1, DYNLL1, RPS28, RPS23, RPS21, RPS20, RPS18, RPS16, RPS13, RPS12, RPS9, RPS8, RPS5, RPS4X, RPS3A, RPS3, FAU, DYNC1LI2, PTBP1, PRUNE2, TSR1, XRCC6, HNRNPD, TARDBP, UBD, BAG3, PROS1, NKX3-1, ITGA4, I
Protein Size: 295

Poids moléculaire: 33 kDa

ID gène: 3921

NCBI Accession: NM_002295, NP_002286

UniProt: P08865

Pathways: Ribonucleoprotein Complex Subunit Organization, Ribosome Assembly