ORC6 anticorps (C-Term)

N° du produit ABIN2786008

Détail du produit anti-ORC6 anticorps

Antigène: ORC6 (Origin Recognition Complex, Subunit 6 (ORC6))

Épitope: C-Term

Reactivité: Humain, Souris, Rat, Chien, Lapin, Boeuf (Vache), Cheval, Cobaye

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ORC6 est non-conjugé

Application: Western Blotting (WB)

Séquence: VEAPAKEMEK VEEMPHKPQK DEDLTQDYEE WKRKILENAA SAQKATAE

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 86%

Attributs du produit: This is a rabbit polyclonal antibody against ORC6L. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the C terminal region of human ORC6L

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 252 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur ORC6

Antigène: ORC6 (Origin Recognition Complex, Subunit 6 (ORC6))

Autre désignation: ORC6L (ORC6 Produits)

Sujet: The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. ORC6L is a subunit of the ORC complex. It has been shown that this protein and and ORC1L are loosely associated with the core complex consisting of ORC2L, -3L, -4L and -5L. Gene silencing studies with small interfering RNA demonstrated that this protein plays an essential role in coordinating chromosome replication and segregation with cytokinesis.The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. It has been shown that this protein and and ORC1L are loosely associated with the core complex consisting of ORC2L, -3L, -4L and -5L. Gene silencing studies with small interfering RNA demonstrated that this protein plays an essential role in coordinating chromosome replication and segregation with cytokinesis. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: ORC6, ORC6L
Protein Interaction Partner: LHX4, SPAG5, UBC, ORC3, CDC7, ORC4, MCM7, MCM6, MCM4, MCM2, CDC6, APP, ORC2, SUMO2, XRCC5, XRCC6, HMGA1, MCM5, TERF2, ORC5, DBF4, CDC45, RPA1,
Protein Size: 252

Poids moléculaire: 28 kDa

ID gène: 23594

NCBI Accession: NM_014321, NP_055136

UniProt: Q9Y5N6

Pathways: Mitotic G1-G1/S Phases, DNA Replication, M Phase, Synthesis of DNA