Sphingomyelin Synthase 1 anticorps (Middle Region)

N° du produit ABIN2786225

Il existe 1 publication pour ce produit. L’anticorps anti-Sphingomyelin Synthase 1 Polyclonal Lapin est utilisé pour la détection de Sphingomyelin Synthase 1 dans des échantillons de Humain, Souris, Rat, Boeuf (Vache), Chien, Cobaye, Cheval, Lapin et Poisson zèbre (Danio rerio). Il a été validé pour WB.

Aperçu rapide pour Sphingomyelin Synthase 1 anticorps (Middle Region) (ABIN2786225)

Antigène: Sphingomyelin Synthase 1 (SGMS1)

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Chien, Cobaye, Cheval, Lapin, Poisson zèbre (Danio rerio)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Sphingomyelin Synthase 1 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-Sphingomyelin Synthase 1 anticorps

Épitope: Middle Region

Fonction: Sgms1 Antibody - middle region

Séquence: LTTVMISVVH ERVPPKEVQP PLPDTFFDHF NRVQWAFSIC EINGMILVGL

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 77%

Attributs du produit: This is a rabbit polyclonal antibody against Sgms1. It was validated on Western Blot.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of Mouse Sgms1

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP55476-100UG

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: prevent freeze-thaw cycles

Stock: 4 °C,-20 °C

Stockage commentaire: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-Sphingomyelin Synthase 1 (ABIN2786225)

Miyamoto, Hsu, Hamm, Darshi, Diamond-Stanic, Declèves, Slater, Pennathur, Stauber, Dorrestein, Sharma: "Mass Spectrometry Imaging Reveals Elevated Glomerular ATP/AMP in Diabetes/obesity and Identifies Sphingomyelin as a Possible Mediator." dans: EBioMedicine, Vol. 7, pp. 121-34, (2016) (PubMed).

Détails sur Sphingomyelin Synthase 1

Antigène: Sphingomyelin Synthase 1 (SGMS1)

Autre désignation: Sgms1

Sujet:

Background Information: Bidirectional lipid cholinephosphotransferase is capable of converting phosphatidylcholine (PC) and ceramide to sphingomyelin (SM) and diacylglycerol (DAG) and vice versa. Direction is dependent on the relative concentrations of DAG and ceramide as phosphocholine acceptors. Sgms1 directly and specifically recognizes the choline head group on the substrate. It also requires two fatty chains on the choline-P donor molecule in order to be recognized efficiently as a substrate. Sgms1 does not function strictly as a SM synthase and suppresses BAX-mediated apoptosis and also prevents cell death in response to stimuli such as hydrogen peroxide, osmotic stress, elevated temperature and exogenously supplied sphingolipids. Sgms1 may protect against cell death by reversing the stress-inducible increase in levels of proapoptotic ceramide.

Alternative Symbols: SM, Mob, Sms1, Sor1, SMS1b, SMS1g, C80702, Tmem23, AI841905, 9530058O11Rik

Protein Name: Phosphatidylcholine:ceramide cholinephosphotransferase 1

Poids moléculaire: 49 kDa

ID gène: 208449

NCBI Accession: NP_659041

UniProt: Q8VCQ6

Pathways: Cellular Response to Molecule of Bacterial Origin