Carabin anticorps (N-Term)

N° du produit ABIN2786421

Cet anticorps Lapin Polyclonal détecte spécifiquement Carabin dans WB. Il présente une réactivité avec des échantillons de Humain, Boeuf (Vache), Rat, Chien, Cobaye, Cheval et Porc.

Aperçu rapide pour Carabin anticorps (N-Term) (ABIN2786421)

Antigène: Carabin (TBC1D10C) (TBC1 Domain Family, Member 10C (TBC1D10C))

Reactivité: Humain, Boeuf (Vache), Rat, Chien, Cobaye, Cheval, Porc

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Carabin est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-Carabin anticorps

Épitope: N-Term

Fonction: TBC1D10C Antibody - N-terminal region

Séquence: MAQALGEDLV QPPELQDDSS SLGSDSELSG PGPYRQADRY GFIGGSSAEP

Homologie: Cow: 86%, Dog: 93%, Guinea Pig: 79%, Horse: 93%, Human: 100%, Pig: 93%, Rat: 79%

Attributs du produit: This is a rabbit polyclonal antibody against TBC1D10C. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human TBC1D10C

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP55893-100UG

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: prevent freeze-thaw cycles

Stock: 4 °C,-20 °C

Stockage commentaire: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Détails sur Carabin

Antigène: Carabin (TBC1D10C) (TBC1 Domain Family, Member 10C (TBC1D10C))

Autre désignation: TBC1D10C

Sujet:

Background Information: TBC1D10C inhibits the Ras signaling pathway through its intrinsic Ras GTPase-activating protein (GAP) activity. TBC1D10C acts as a negative feedback inhibitor of the calcineurin signaling pathway that also mediates crosstalk between calcineurin and Ras.Carabin is an endogenous inhibitor of calcineurin (see MIM 114105) that also inhibits the Ras (see MIM 190020) signaling pathway through its intrinsic Ras GTPase-activating protein activity (Pan et al., 2007 [PubMed 17230191]).[supplied by OMIM].

Gene Name: TBC1 domain family, member 10C

Alternative Symbols: EPI64C, CARABIN

Protein Name: Carabin

Poids moléculaire: 50kDa

ID gène: 374403

NCBI Accession: NP_940919

UniProt: Q8IV04