HERV-FRD Provirus Ancestral Env Polyprotein (Herv-frd) (N-Term) anticorps

N° du produit ABIN2786479

Détail du produit

Antigène: HERV-FRD Provirus Ancestral Env Polyprotein (Herv-frd)

Épitope: N-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Inconjugué

Application: Western Blotting (WB)

Séquence: TGSPYSTNCW LCTSSSTETP GTAYPASPRE WTSIEAELHI SYRWDPNLKG

Homologie: Human: 100%

Attributs du produit: This is a rabbit polyclonal antibody against HERV-FRD. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human HERV-FRD

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 538 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Référence

Malassiné, Frendo, Blaise, Handschuh, Gerbaud, Tsatsaris, Heidmann, Evain-Brion: "Human endogenous retrovirus-FRD envelope protein (syncytin 2) expression in normal and trisomy 21-affected placenta." dans: Retrovirology, Vol. 5, pp. 6, (2008) (PubMed).

Détail du antigène

Antigène: HERV-FRD Provirus Ancestral Env Polyprotein (Herv-frd)

Autre désignation: HERV-FRD (Herv-frd Produits)

Synonymes: anticorps ERVFRDE1, anticorps GLLL6191, anticorps HERV-FRD, anticorps HERV-W/FRD, anticorps UNQ6191, anticorps envFRD, anticorps Gm52, anticorps Syna, anticorps endogenous retrovirus group FRD member 1, envelope, anticorps ERVFRD-1, anticorps Ervfrd-1

Classe de substances: Viral Protein

Sujet: Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution. This endogenous envelope protein has retained its original fusogenic properties. HERV-FRD can make pseudotypes with MLV, HIV-1 or SIV-1 virions and confer infectivity.Human endogenous retroviruses (HERVs) make up approximately 8 % of the human genome. Although most HERVs are nonfunctional, the HERV-W (ERVWE1, MIM 604659) and HERV-FRD envelope (env) proteins can induce cell-cell fusion when expressed in cells possessing appropriate receptors (Blaise et al., 2003 [PubMed 14557543]).[supplied by OMIM].
Alias Symbols: FLJ41944, FLJ90611, GLLL6191, MGC87585, UNQ6191, envFRD, ERVFRDE1, HERV-FRD, HERV-W/FRD
Protein Interaction Partner: APP,
Protein Size: 538

Poids moléculaire: 60 kDa

ID gène: 405754

NCBI Accession: NM_207582, NP_997465

UniProt: P60508