NPHP1 anticorps (Middle Region)

N° du produit ABIN2786505

Détail du produit anti-NPHP1 anticorps

Antigène: NPHP1 (Nephronophthisis 1 (Juvenile) (NPHP1))

Épitope: Middle Region

Reactivité: Humain, Souris, Rat, Chien, Cheval, Porc, Lapin, Boeuf (Vache), Cobaye, Poisson zèbre (Danio rerio)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NPHP1 est non-conjugé

Application: Western Blotting (WB)

Séquence: GILFELGISY IRNSTGERGE LSCGWVFLKL FDASGVPIPA KTYELFLNGG

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 92%

Attributs du produit: This is a rabbit polyclonal antibody against NPHP1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human NPHP1

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 733 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur NPHP1

Antigène: NPHP1 (Nephronophthisis 1 (Juvenile) (NPHP1))

Autre désignation: NPHP1 (NPHP1 Produits)

Synonymes: anticorps JBTS4, anticorps NPH1, anticorps SLSN1, anticorps nephrocystin-1, anticorps NPHP1, anticorps im:7162391, anticorps wu:fi59g07, anticorps zgc:152930, anticorps Nphp1, anticorps nephrocystin 1, anticorps nephronophthisis 1 (juvenile) homolog (human), anticorps nephronophthisis 1 (juvenile) L homeolog, anticorps nephronophthisis 1, anticorps nephrocystin-1, anticorps NPHP1, anticorps Nphp1, anticorps nphp1.L, anticorps nphp1, anticorps LOC100725987

Sujet: Together with Cas NPHP1 may play a role in the control of epithelial cell polarity. NPHP1 seems to help to recruit protein tyrosine kinase 2 beta (PTK2B) to cell matrix adhesions, thereby initiating phosphorylation of PTK2B and PTK2B-dependent signaling.This gene encodes a protein with src homology domain 3 (SH3) patterns. This protein interacts with Crk-associated substrate, and it appears to function in the control of cell division, as well as in cell-cell and cell-matrix adhesion signaling, likely as part of a multifunctional complex localized in actin- and microtubule-based structures. Mutations in this gene cause familial juvenile nephronophthisis type 1, a kidney disorder involving both tubules and glomeruli. Defects in this gene are also associated with Senior-Loken syndrome type 1, also referred to as juvenile nephronophthisis with Leber amaurosis, which is characterized by kidney and eye disease, and with Joubert syndrome type 4, which is characterized by cerebellar ataxia, oculomotor apraxia, psychomotor delay and neonatal breathing abnormalities, sometimes including retinal dystrophy and renal disease. Multiple transcript variants encoding different isoforms have been found for this gene.
Alias Symbols: JBTS4, NPH1, SLSN1
Protein Interaction Partner: MED28, CEP164, ADAM15, UBQLN4, TNK2, ARHGAP32, BCAR1, KHDRBS1, UBC, NPHP1, INVS, NPHP3, NPHP4, PAK2, FLNB, PTK2B, FLNA, TUBB, FLNC, TNS1,
Protein Size: 733

Poids moléculaire: 83 kDa

ID gène: 4867

NCBI Accession: NM_000272, NP_000263