BLMH anticorps (Middle Region)

N° du produit ABIN2786515

Cet anticorps anti-BLMH Polyclonal Lapin (ABIN2786515) détecte spécifiquement BLMH dans WB. L’anticorps est réactif avec des échantillons de Humain, Rat, Souris, Chien, Cobaye, Poisson zèbre (Danio rerio), Boeuf (Vache), Cheval et Lapin.

Aperçu rapide pour BLMH anticorps (Middle Region) (ABIN2786515)

Antigène: BLMH (Bleomycin Hydrolase (BLMH))

Reactivité: Humain, Rat, Souris, Chien, Cobaye, Poisson zèbre (Danio rerio), Boeuf (Vache), Cheval, Lapin

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp BLMH est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-BLMH anticorps

Épitope: Middle Region

Fonction: BLMH Antibody - middle region

Séquence: EYLSNMVGGR KTLYNNQPID FLKKMVAASI KDGEAVWFGC DVGKHFNSKL

Homologie: Cow: 93%, Dog: 100%, Guinea Pig: 100%, Horse: 93%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 85%

Attributs du produit: This is a rabbit polyclonal antibody against BLMH. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human BLMH

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP56106-100UG

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: prevent freeze-thaw cycles

Stock: 4 °C,-20 °C

Stockage commentaire: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Détails sur BLMH

Antigène: BLMH (Bleomycin Hydrolase (BLMH))

Autre désignation: BLMH

Sujet:

Background Information: The normal physiological role of BLM hydrolase is unknown, but it catalyzes the inactivation of the antitumor drug BLM (a glycopeptide) by hydrolyzing the carboxamide bond of its B-aminoalaninamide moiety thus protecting normal and malignant cells from BLM toxicity.Bleomycin hydrolase (BMH) is a cytoplasmic cysteine peptidase that is highly conserved through evolution, however, the only known activity of the enzyme is metabolic inactivation of the glycopeptide bleomycin (BLM), an essential component of combination chemotherapy regimens for cancer. The protein contains the signature active site residues of the cysteine protease papain superfamily. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

Gene Name: Bleomycin hydrolase

Alternative Symbols: BH, BMH

Protein Name: Bleomycin hydrolase

Poids moléculaire: 52kDa

ID gène: 642

NCBI Accession: NP_000377

UniProt: Q13867