MVK anticorps (N-Term)

N° du produit ABIN2786518

Cet anticorps anti-MVK Polyclonal Lapin (ABIN2786518) détecte spécifiquement MVK dans WB et IHC. L’anticorps est réactif avec des échantillons de Humain, Souris, Rat, Cobaye, Cheval, Boeuf (Vache), Chien, Lapin et Poisson zèbre (Danio rerio).

Aperçu rapide pour MVK anticorps (N-Term) (ABIN2786518)

Antigène: MVK (Mevalonate Kinase (MVK))

Reactivité: Humain, Souris, Rat, Cobaye, Cheval, Boeuf (Vache), Chien, Lapin, Poisson zèbre (Danio rerio)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MVK est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Détail du produit anti-MVK anticorps

Épitope: N-Term

Fonction: MVK Antibody - N-terminal region

Séquence: LAVLAFLYLY LSICRKQRAL PSLDIVVWSE LPPGAGLGSS AAYSVCLAAA

Homologie: Cow: 93%, Dog: 93%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 93%, Rat: 100%, Zebrafish: 93%

Attributs du produit: This is a rabbit polyclonal antibody against MVK. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human MVK

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP56109-100UG

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: prevent freeze-thaw cycles

Stock: 4 °C,-20 °C

Stockage commentaire: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Détails sur MVK

Antigène: MVK (Mevalonate Kinase (MVK))

Autre désignation: MVK

Sujet:

Background Information: MVK is the peroxisomal enzyme mevalonate kinase. Mevalonate is a key intermediate, and mevalonate kinase a key early enzyme, in isoprenoid and sterol synthesis. Mevalonate kinase deficiency caused by mutation of this gene results in mevalonic aciduria, a disease characterized psychomotor retardation, failure to thrive, hepatosplenomegaly, anemia and recurrent febrile crises. Defects in this gene also cause hyperimmunoglobulinaemia D and periodic fever syndrome, a disorder characterized by recurrent episodes of fever associated with lymphadenopathy, arthralgia, gastrointestinal dismay and skin rash.This gene encodes the peroxisomal enzyme mevalonate kinase. Mevalonate is a key intermediate, and mevalonate kinase a key early enzyme, in isoprenoid and sterol synthesis. Mevalonate kinase deficiency caused by mutation of this gene results in mevalonic aciduria, a disease characterized psychomotor retardation, failure to thrive, hepatosplenomegaly, anemia and recurrent febrile crises. Defects in this gene also cause hyperimmunoglobulinaemia D and periodic fever syndrome, a disorder characterized by recurrent episodes of fever associated with lymphadenopathy, arthralgia, gastrointestinal dismay and skin rash. Two transcript variants that encode the same protein have been found for this gene.

Gene Name: Mevalonate kinase

Alternative Symbols: MK, LRBP, MVLK, POROK3

Protein Name: Mevalonate kinase

Poids moléculaire: 42kDa

ID gène: 4598

NCBI Accession: NP_000422

UniProt: Q03426