AKTIP anticorps (Middle Region)

N° du produit ABIN2786570

Cité dans 1 publication. Cet anticorps anti-AKTIP Polyclonal Lapin (ABIN2786570) détecte spécifiquement AKTIP dans WB. L’anticorps est réactif avec des échantillons de Humain, Souris, Rat, Chien, Poisson zèbre (Danio rerio), Boeuf (Vache), Cobaye, Cheval et Lapin.

Aperçu rapide pour AKTIP anticorps (Middle Region) (ABIN2786570)

Antigène: AKTIP (AKT Interacting Protein (AKTIP))

Reactivité: Humain, Souris, Rat, Chien, Poisson zèbre (Danio rerio), Boeuf (Vache), Cobaye, Cheval, Lapin

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp AKTIP est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-AKTIP anticorps

Épitope: Middle Region

Fonction: AKTIP Antibody - middle region

Séquence: NPSVHDEARE KMLTQKKPEE QHNKSVHVAG LSWVKPGSVQ PFSKEEKTVA

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 83%

Attributs du produit: This is a rabbit polyclonal antibody against AKTIP. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human AKTIP

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP56199-100UG

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: prevent freeze-thaw cycles

Stock: 4 °C,-20 °C

Stockage commentaire: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-AKTIP (ABIN2786570)

Ewing, Chu, Elisma, Li, Taylor, Climie, McBroom-Cerajewski, Robinson, OConnor, Li, Taylor, Dharsee, Ho, Heilbut, Moore, Zhang, Ornatsky, Bukhman, Ethier, Sheng, Vasilescu, Abu-Farha, Lambert, Duewel et al.: "Large-scale mapping of human protein-protein interactions by mass spectrometry. ..." dans: Molecular systems biology, Vol. 3, pp. 89, (2007) (PubMed).

Détails sur AKTIP

Antigène: AKTIP (AKT Interacting Protein (AKTIP))

Autre désignation: AKTIP

Sujet:

Background Information: AKTIP is the component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). AKTIP regulates apoptosis by enhancing phosphorylation and activation of AKT1. AKTIP increases release of TNFSF6 via the AKT1/GSK3B/NFATC1 signaling cascade.The mouse homolog of this gene produces fused toes and thymic hyperplasia in heterozygous mutant animals while homozygous mutants die in early development. This gene may play a role in apoptosis as these morphological abnormalities are caused by altered patterns of programmed cell death. The protein encoded by this gene is similar to the ubiquitin ligase domain of other ubiquitin-conjugating enzymes but lacks the conserved cysteine residue that enables those enzymes to conjugate ubiquitin to the target protein. This protein interacts directly with serine/threonine kinase protein kinase B (PKB)/Akt and modulates PKB activity by enhancing the phosphorylation of PKB's regulatory sites. Alternative splicing results in two transcript variants encoding the same protein.

Gene Name: AKT interacting protein

Alternative Symbols: FT1, FTS

Protein Name: AKT-interacting protein

Poids moléculaire: 33kDa

ID gène: 64400

NCBI Accession: NP_001012398

UniProt: Q9H8T0