PDE4B anticorps (Middle Region)

N° du produit ABIN2786603

Cet anticorps Lapin Polyclonal détecte spécifiquement PDE4B dans WB. Il présente une réactivité envers Humain, Rat, Souris, Boeuf (Vache), Chien, Cobaye, Cheval, Porc et Lapin et a été mentionné dans 1 publication.

Aperçu rapide pour PDE4B anticorps (Middle Region) (ABIN2786603)

Antigène: PDE4B (phosphodiesterase 4B, cAMP-Specific (PDE4B))

Reactivité: Humain, Rat, Souris, Boeuf (Vache), Chien, Cobaye, Cheval, Porc, Lapin

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PDE4B est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-PDE4B anticorps

Épitope: Middle Region

Séquence: QDILDTLEDN RNWYQSMIPQ SPSPPLDEQN RDCQGLMEKF QFELTLDEED

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 83%, Horse: 100%, Human: 100%, Mouse: 86%, Pig: 100%, Rabbit: 93%, Rat: 93%

Attributs du produit: This is a rabbit polyclonal antibody against PDE4B. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human PDE4B

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 564 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-PDE4B (ABIN2786603)

Fatemi, King, Reutiman, Folsom, Laurence, Lee, Fan, Paciga, Conti, Menniti: "PDE4B polymorphisms and decreased PDE4B expression are associated with schizophrenia." dans: Schizophrenia research, Vol. 101, Issue 1-3, pp. 36-49, (2008) (PubMed).

Détails sur PDE4B

Antigène: PDE4B (phosphodiesterase 4B, cAMP-Specific (PDE4B))

Autre désignation: PDE4B

Sujet: The specific function of this protein remains unknown.This gene is a member of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family. Cyclic nucleotides are important second messengers that regulate and mediate a number of cellular responses to extracellular signals, such as hormones, light, and neurotransmitters. The cyclic nucleotide phosphodiesterases (PDEs) regulate the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. This gene encodes a protein that specifically hydrolyzes cAMP. Altered activity of this protein has been associated with schizophrenia and bipolar affective disorder. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Alias Symbols: DKFZp686F2182, DPDE4, MGC126529, PDE4B5, PDEIVB
Protein Interaction Partner: MAGEA11, RCBTB2, APOA1, ALB, PAFAH1B1, UBC, DISC1, PRKACA,
Protein Size: 564

Poids moléculaire: 64 kDa

ID gène: 5142

NCBI Accession: NM_001037339, NP_001032416

UniProt: Q5TEK5

Pathways: Cellular Response to Molecule of Bacterial Origin, cAMP Metabolic Process, Myometrial Relaxation and Contraction