PRELP anticorps (Middle Region)

N° du produit ABIN2786687

Cet anticorps Lapin Polyclonal détecte spécifiquement PRELP dans WB. Il présente une réactivité avec des échantillons de Humain, Souris, Rat, Boeuf (Vache), Chien, Cobaye, Cheval, Porc et Lapin.

Aperçu rapide pour PRELP anticorps (Middle Region) (ABIN2786687)

Antigène: PRELP (Proline Arginine Rich End Leucine Rich Repeat Protein (PRELP))

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Chien, Cobaye, Cheval, Porc, Lapin

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PRELP est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-PRELP anticorps

Épitope: Middle Region

Fonction: PRELP Antibody - middle region

Séquence: SNKIETIPNG YFKSFPNLAF IRLNYNKLTD RGLPKNSFNI SNLLVLHLSH

Homologie: Cow: 86%, Dog: 86%, Guinea Pig: 86%, Horse: 86%, Human: 100%, Mouse: 93%, Pig: 93%, Rabbit: 86%, Rat: 93%

Attributs du produit: This is a rabbit polyclonal antibody against PRELP. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human PRELP

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP56412-100UG

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: prevent freeze-thaw cycles

Stock: 4 °C,-20 °C

Stockage commentaire: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Détails sur PRELP

Antigène: PRELP (Proline Arginine Rich End Leucine Rich Repeat Protein (PRELP))

Autre désignation: PRELP

Sujet:

Background Information: PRELP is a leucine-rich repeat protein present in connective tissue extracellular matrix. This protein functions as a molecule anchoring basement membranes to the underlying connective tissue. This protein has been shown to bind type I collagen to basement membranes and type II collagen to cartilage. It also binds the basement membrane heparan sulfate proteoglycan perlecan. This protein is suggested to be involved in the pathogenesis of Hutchinson-Gilford progeria (HGP), which is reported to lack the binding of collagen in basement membranes and cartilage.The protein encoded by this gene is a leucine-rich repeat protein present in connective tissue extracellular matrix. This protein functions as a molecule anchoring basement membranes to the underlying connective tissue. This protein has been shown to bind type I collagen to basement membranes and type II collagen to cartilage. It also binds the basement membrane heparan sulfate proteoglycan perlecan. This protein is suggested to be involved in the pathogenesis of Hutchinson-Gilford progeria (HGP), which is reported to lack the binding of collagen in basement membranes and cartilage. Alternatively spliced transcript variants encoding the same protein have been observed.

Gene Name: Proline/arginine-rich end leucine-rich repeat protein

Alternative Symbols: MST161, SLRR2A, MSTP161

Protein Name: Prolargin

Poids moléculaire: 42kDa

ID gène: 5549

NCBI Accession: NP_002716

UniProt: P51888

Pathways: Glycosaminoglycan Metabolic Process