C11orf73 anticorps (Middle Region)

N° du produit ABIN2786966

Cet anticorps anti-C11orf73 Polyclonal Lapin (ABIN2786966) détecte spécifiquement C11orf73 dans WB. L’anticorps est réactif avec des échantillons de Humain, Souris, Rat, Cheval, Boeuf (Vache), Chien, Cobaye, Lapin, Poisson zèbre (Danio rerio), Porc et Saccharomyces cerevisiae.

Aperçu rapide pour C11orf73 anticorps (Middle Region) (ABIN2786966)

Antigène: C11orf73 (Chromosome 11 Open Reading Frame 73 (C11orf73))

Reactivité: Humain, Souris, Rat, Cheval, Boeuf (Vache), Chien, Cobaye, Lapin, Poisson zèbre (Danio rerio), Porc, Saccharomyces cerevisiae

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp C11orf73 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-C11orf73 anticorps

Épitope: Middle Region

Fonction: HIKESHI Antibody - middle region

Séquence: DNFYNFASSF AVSQAQMTPS PSEMFIPANV VLKWYENFQR RLAQNPLFWK

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 90%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 93%, Rat: 100%, Yeast: 90%, Zebrafish: 86%

Attributs du produit: This is a rabbit polyclonal antibody against C11orf73. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human C11orf73

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP56903-100UG

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: prevent freeze-thaw cycles

Stock: 4 °C,-20 °C

Stockage commentaire: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Détails sur C11orf73

Antigène: C11orf73 (Chromosome 11 Open Reading Frame 73 (C11orf73))

Autre désignation: HIKESHI

Sujet:

Background Information: This gene encodes an evolutionarily conserved nuclear transport receptor that mediates heat-shock-induced nuclear import of 70 kDa heat-shock proteins (Hsp70s) through interactions with FG-nucleoporins. The protein mediates transport of the ATP form but not the ADP form of Hsp70 proteins under conditions of heat shock stress. Structural analyses demonstrate that the protein forms an asymmetric homodimer and that the N-terminal domain consists of a jelly-roll/beta-sandwich fold structure that contains hydrophobic pockets involved in FG-nucleoporin recognition. Reduction of RNA expression levels in HeLa cells using small interfering RNAs results in inhibition of heat shock-induced nuclear accumulation of Hsp70s, indicating a role for this gene in regulation of Hsp70 nuclear import during heat shock stress.

Gene Name: Hikeshi, heat shock protein nuclear import factor

Alternative Symbols: HLD13, L7RN6, OPI10, HSPC138, HSPC179, C11orf73

Protein Name: protein Hikeshi

Poids moléculaire: 21kDa

ID gène: 51501

NCBI Accession: NP_057485

UniProt: Q53FT3

Pathways: Protein targeting to Nucleus