MTRR anticorps (N-Term)

N° du produit ABIN2787324

1 publication est disponible pour ce produit. L’anticorps anti-MTRR Polyclonal produit chez le Lapin a été validé pour WB et IHC. Il convient pour la détection de MTRR dans des échantillons provenant de Humain, Souris, Rat, Chien, Lapin, Boeuf (Vache), Cobaye, Cheval et Porc. }

Aperçu rapide pour MTRR anticorps (N-Term) (ABIN2787324)

Antigène: MTRR (5-Methyltetrahydrofolate-Homocysteine Methyltransferase Reductase (MTRR))

Reactivité: Humain, Souris, Rat, Chien, Lapin, Boeuf (Vache), Cobaye, Cheval, Porc

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MTRR est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Détail du produit anti-MTRR anticorps

Épitope: N-Term

Séquence: YDLKTETAPL VVVVSTTGTG DPPDTARKFV KEIQNQTLPV DFFAHLRYGL

Homologie: Cow: 93%, Dog: 100%, Guinea Pig: 93%, Horse: 93%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%

Attributs du produit: This is a rabbit polyclonal antibody against MTRR. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human MTRR

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 725 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-MTRR (ABIN2787324)

Richard, Desviat, Ugarte, Pérez: "Oxidative stress and apoptosis in homocystinuria patients with genetic remethylation defects." dans: Journal of cellular biochemistry, Vol. 114, Issue 1, pp. 183-91, (2012) (PubMed).

Détails sur MTRR

Antigène: MTRR (5-Methyltetrahydrofolate-Homocysteine Methyltransferase Reductase (MTRR))

Autre désignation: MTRR

Sujet: Methionine is an essential amino acid required for protein synthesis and one-carbon metabolism. Its synthesis is catalyzed by the enzyme methionine synthase. Methionine synthase eventually becomes inactive due to the oxidation of its cob(I)alamin cofactor. The protein encoded by this gene regenerates a functional methionine synthase via reductive methylation. It is a member of the ferredoxin-NADP(+) reductase (FNR) family of electron transferases. Patients of the cbl-E complementation group of disorders of folate/cobalamin metabolism are defective in reductive activation of methionine synthase. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms.
Alias Symbols: MGC129643, MSR, cblE
Protein Interaction Partner: GMCL1, PAPSS1, HIST1H2AG, FH, ELAVL1, UBC, MMAB,
Protein Size: 725

Poids moléculaire: 80 kDa

ID gène: 4552

NCBI Accession: NM_024010, NP_076915

UniProt: Q9UBK8

Pathways: Methionine Biosynthetic Process