CEBPA anticorps (Middle Region)

N° du produit ABIN2787465

L’anticorps Lapin Polyclonal anti-CEBPA a été validé pour WB et IHC. Il convient pour détecter CEBPA dans des échantillons de Humain, Souris, Rat, Boeuf (Vache), Poisson zèbre (Danio rerio), Cobaye, Chien, Lapin, Cheval et Mouton. Il y a 2+ publications disponibles.

Aperçu rapide pour CEBPA anticorps (Middle Region) (ABIN2787465)

Antigène: CEBPA (CCAAT/enhancer Binding Protein (C/EBP), alpha (CEBPA))

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Poisson zèbre (Danio rerio), Cobaye, Chien, Lapin, Cheval, Mouton

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CEBPA est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Détail du produit anti-CEBPA anticorps

Épitope: Middle Region

Séquence: RRERNNIAVR KSRDKAKQRN VETQQKVLEL TSDNDRLRKR VEQLSRELDT

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 79%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Sheep: 79%, Zebrafish: 93%

Attributs du produit: This is a rabbit polyclonal antibody against CEBPA. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human CEBPA

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 358 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-CEBPA (ABIN2787465)

Miglino, Roth, Tamm, Borger: "House dust mite extract downregulates C/EBP? in asthmatic bronchial smooth muscle cells." dans: The European respiratory journal, Vol. 38, Issue 1, pp. 50-8, (2011) (PubMed).

Borger, Miglino, Baraket, Black, Tamm, Roth: "Impaired translation of CCAAT/enhancer binding protein alpha mRNA in bronchial smooth muscle cells of asthmatic patients." dans: The Journal of allergy and clinical immunology, Vol. 123, Issue 3, pp. 639-45, (2009) (PubMed).

Détails sur CEBPA

Antigène: CEBPA (CCAAT/enhancer Binding Protein (C/EBP), alpha (CEBPA))

Autre désignation: CEBPA

Sujet: CEBPA is a bZIP transcription factor which can bind as a homodimer to certain promoters and enhancers. It can form heterodimers with the related proteins CEBP-beta and CEBP-gamma. The protein has been shown to bind to the promoter and modulate the expression of the gene encoding leptin, a protein that plays an important role in body weight homeostasis. Also, CEBPA can interact with CDK2 and CDK4, thereby inhibiting these kinases and causing growth arrest in cultured cells.The protein encoded by this intronless gene is a bZIP transcription factor which can bind as a homodimer to certain promoters and enhancers. It can also form heterodimers with the related proteins CEBP-beta and CEBP-gamma. The encoded protein has been shown to bind to the promoter and modulate the expression of the gene encoding leptin, a protein that plays an important role in body weight homeostasis. Also, the encoded protein can interact with CDK2 and CDK4, thereby inhibiting these kinases and causing growth arrest in cultured cells. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. PRIMARYREFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-2385 U34070.1 592-2976
Alias Symbols: C/EBP-alpha, CEBP
Protein Interaction Partner: CEBPB, ZBTB16, RARA, HDAC1, BHLHE41, UBC, CEBPE, BATF2, BATF3, YY1AP1, ATF5, BATF, FOSL1, FOS, DBP, CEBPG, CEBPA, ATF4, ATF3, UBE3A, SKP2, RASGRF1, C1QBP, CDKN1A, SRA1, CDK4, PIAS1, Fbxw7, GRIN3A, RAB34, NAA16, POLR1E, MRTO4, AK5, MACF1, KAT5, AKAP9, SMC1
Protein Size: 358

Poids moléculaire: 37 kDa

ID gène: 1050

NCBI Accession: NM_004364, NP_004355

UniProt: P49715

Pathways: Brown Fat Cell Differentiation, Positive Regulation of fat Cell Differentiation