ATF5 anticorps (Middle Region)

N° du produit ABIN2787491

Cet anticorps Lapin Polyclonal détecte spécifiquement ATF5 dans WB. Il présente une réactivité envers Humain, Souris, Rat, Boeuf (Vache), Cobaye, Cheval, Poisson zèbre (Danio rerio) et Chien et a été mentionné dans 1 publication.

Aperçu rapide pour ATF5 anticorps (Middle Region) (ABIN2787491)

Antigène: ATF5 (Activating Transcription Factor 5 (ATF5))

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Cobaye, Cheval, Poisson zèbre (Danio rerio), Chien

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ATF5 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-ATF5 anticorps

Épitope: Middle Region

Séquence: LPPPQQPPPP SPPQPSRLAP YPHPATTRGD RKQKKRDQNK SAALRYRQRK

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rat: 100%, Zebrafish: 93%

Attributs du produit: This is a rabbit polyclonal antibody against ATF5. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human ATF5

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 282 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-ATF5 (ABIN2787491)

Wei, Jiang, Liu, Zhou, Chen, Zhang, Zong, Yun, Gu: "Cdc34-mediated degradation of ATF5 is blocked by cisplatin." dans: The Journal of biological chemistry, Vol. 283, Issue 27, pp. 18773-81, (2008) (PubMed).

Détails sur ATF5

Antigène: ATF5 (Activating Transcription Factor 5 (ATF5))

Autre désignation: ATF5

Sujet: ATF5 belongs to the bZIP family. It is transcriptional activator which binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters and blocks the differentiation of neuroprogenitor cells into neurons. Its transcriptional activity is enhanced by CCND3 and slightly inhibited by CDK4. Loss of ATF5 is associated with hepatocellular carcinoma.
Alias Symbols: ATFX, FLJ34666, HMFN0395
Protein Interaction Partner: CEBPE, CEBPA, GIT2, ATXN1, EP300, CCND3, GABBR2, DISC1, GABBR1, CEBPG, CDC34, TRIB3, UBC, CD34,
Protein Size: 282

Poids moléculaire: 31 kDa

ID gène: 22809

NCBI Accession: NM_012068, NP_036200

UniProt: B3KND3

Pathways: Myometrial Relaxation and Contraction