PPP4C anticorps (Middle Region)

N° du produit ABIN2787719

Détail du produit anti-PPP4C anticorps

Antigène: PPP4C (Protein Phosphatase 4, Catalytic Subunit (PPP4C))

Épitope: Middle Region

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Chien, Lapin, Cheval, Cobaye, Poisson zèbre (Danio rerio), Saccharomyces cerevisiae

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PPP4C est non-conjugé

Application: Western Blotting (WB)

Séquence: TVLTVWSAPN YCYRCGNVAA ILELDEHLQK DFIIFEAAPQ ETRGIPSKKP

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Yeast: 79%, Zebrafish: 100%

Attributs du produit: This is a rabbit polyclonal antibody against PPP4C. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human PPP4C

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 307 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur PPP4C

Antigène: PPP4C (Protein Phosphatase 4, Catalytic Subunit (PPP4C))

Autre désignation: PPP4C (PPP4C Produits)

Synonymes: anticorps pp4, anticorps ppx, anticorps pp4c, anticorps pph3, anticorps MGC75928, anticorps PP4C-A, anticorps gc:56413, anticorps ppp4c, anticorps wu:fd05e08, anticorps zgc:56413, anticorps PP4, anticorps PP4C, anticorps PPH3, anticorps PPP4, anticorps PPX, anticorps 1110002D08Rik, anticorps AU016079, anticorps Ppx, anticorps protein phosphatase 4 catalytic subunit, anticorps protein phosphatase 4, catalytic subunit a, anticorps protein phosphatase 4, catalytic subunit, anticorps protein phosphatase 4 catalytic subunit S homeolog, anticorps ppp4c, anticorps ppp4ca, anticorps PPP4C, anticorps Ppp4c, anticorps ppp4c.S

Sujet: PPP4C is a protein phosphatase that is involved in many processes such as microtubule organization at centrosomes, maturation of spliceosomal snRNPs, apoptosis, tumor necrosis factor (TNF)-alpha signaling, activation of c-Jun N-terminal kinase MAPK8, regulation of histone acetylation, DNA damage checkpoint signaling, NF-kappa-B activation and cell migration. The PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on Ser-140 (gamma-H2AFX) generated during DNA replication and required for DNA DSB repair. Dephosphorylates NDEL1 at CDC2/Cdk1 phosphorylation sites and negatively regulates CDC2/Cdk1 activity in interphase.
Alias Symbols: PP4, PPH3, PPX, PP4C, PPP4
Protein Interaction Partner: SUMO2, IKBKG, MAP4K1, BAG6, TCP1, UBC, CAND1, CUL3, Igbp1, TRIM28, ELAVL1, TK1, PPP2R5D, PPP2R4, PPP2R2B, PPP2R1A, EEF1A1, CCT6A, SMEK2, PPP2R2D, SMEK1, ATAD3A, PPME1, CCT5, CCT8, CCT2, CCT4, CCT7, PPP4R1, PLOD3, CCDC6, TUBA3C, CCT3, CCT6P1, GLYATL3, PPP4
Protein Size: 307

Poids moléculaire: 34 kDa

ID gène: 5531

NCBI Accession: NM_002720, NP_002711

UniProt: P60510