FN3KRP anticorps (N-Term)

N° du produit ABIN2787771

Détail du produit anti-FN3KRP anticorps

Antigène: FN3KRP (Fructosamine 3 Kinase Related Protein (FN3KRP))

Épitope: N-Term

Reactivité: Humain, Souris, Rat, Lapin, Boeuf (Vache), Poisson zèbre (Danio rerio), Chien, Cobaye, Cheval

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FN3KRP est non-conjugé

Application: Western Blotting (WB)

Séquence: MDPGDPAGDP AAGERHRMGR DPLLLLQALQ TLWSTRERKQ LREEAWRGFA

Homologie: Cow: 86%, Dog: 86%, Guinea Pig: 86%, Horse: 86%, Human: 100%, Mouse: 86%, Rabbit: 86%, Rat: 93%, Zebrafish: 79%

Attributs du produit: This is a rabbit polyclonal antibody against FN3KRP. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human FN3KRP

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 309 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-FN3KRP (ABIN2787771)

Szwergold, Manevich, Payne, Loomes: "Fructosamine-3-kinase-related-protein phosphorylates glucitolamines on the C-4 hydroxyl: novel substrate specificity of an enigmatic enzyme." dans: Biochemical and biophysical research communications, Vol. 361, Issue 4, pp. 870-5, (2007) (PubMed).

Détails sur FN3KRP

Antigène: FN3KRP (Fructosamine 3 Kinase Related Protein (FN3KRP))

Autre désignation: FN3KRP (FN3KRP Produits)

Synonymes: anticorps FN3KL, anticorps FN3K-RP, anticorps fn3k, anticorps fn3kl, anticorps MGC145992, anticorps DKFZP469K211, anticorps RGD1304570, anticorps zgc:101634, anticorps fructosamine 3 kinase related protein, anticorps fructosamine-3-kinase-related protein, anticorps FN3KRP, anticorps Fn3krp, anticorps fn3krp

Sujet: FN3KRP phosphorylates psicosamines and ribulosamines, but not fructosamines, on the third carbon of the sugar moiety. Protein-bound psicosamine 3-phosphates and ribulosamine 3-phosphates are unstable and decompose under physiological conditions. Thus phosphorylation leads to deglycation.FN3KRP and FN3K (MIM 608425) protect proteins from nonenzymatic glycation by phosphorylating the modified amino acid. This phosphorylation destabilizes the sugar-amine linkage and leads to spontaneous decomposition (Conner et al., 2004 [PubMed 15381090]).[supplied by OMIM].
Alias Symbols: FLJ12171, FN3KL
Protein Interaction Partner: APP, CUL3, CUL4B, UBC, USP43,
Protein Size: 309

Poids moléculaire: 34 kDa

ID gène: 79672

NCBI Accession: NM_024619, NP_078895

UniProt: Q9HA64