MVP anticorps (N-Term)

N° du produit ABIN2787778

Cet anticorps anti-MVP Polyclonal Lapin (ABIN2787778) détecte spécifiquement MVP dans WB. L’anticorps est réactif avec des échantillons de Humain, Souris, Rat, Boeuf (Vache), Lapin, Poisson zèbre (Danio rerio), Chien, Cheval, Cobaye et Porc.

Aperçu rapide pour MVP anticorps (N-Term) (ABIN2787778)

Antigène: MVP (Major Vault Protein (MVP))

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Lapin, Poisson zèbre (Danio rerio), Chien, Cheval, Cobaye, Porc

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MVP est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-MVP anticorps

Épitope: N-Term

Séquence: MATEEFIIRI PPYHYIHVLD QNSNVSRVEV GPKTYIRQDN ERVLFAPMRM

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 86%

Attributs du produit: This is a rabbit polyclonal antibody against MVP. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human MVP

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 893 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur MVP

Antigène: MVP (Major Vault Protein (MVP))

Autre désignation: MVP

Sujet: MVP is required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport. MVP down-regulates INFG-mediated STAT1 signaling and subsequent activation of JAK. MVP down-regulates SRC activity and signaling through MAP kinases.This gene encodes the major vault protein which is a lung resistance-related protein. Vaults are multi-subunit structures that may be involved in nucleo-cytoplasmic transport. This protein mediates drug resistance, perhaps via a transport process. It is widely distributed in normal tissues, and overexpressed in multidrug-resistant cancer cells. The protein overexpression is a potentially useful marker of clinical drug resistance. This gene produces two transcripts by using two alternative exon 2 sequences, however, the open reading frames are the same in both transcripts.
Alias Symbols: LRP, VAULT1
Protein Interaction Partner: MVP, SKIL, TRIM27, REL, PLSCR1, MEOX2, MEOX1, MDFI, KPNA3, GOLGA2, DLX2, CAMK2B, AES, TRIP6, TRAF2, TP53, TFCP2, TCF4, SUMO2, NOTCH2NL, CCDC36, TRIM42, FAM154A, PIH1D2, RAB3IP, RIMBP3, C1orf94, RHOXF2, ZMIZ2, OBFC1, RFWD2, MKL1, VAC14, BANP, FAM46C, KCTD9
Protein Size: 893

Poids moléculaire: 98 kDa

ID gène: 9961

NCBI Accession: NM_005115, NP_005106

UniProt: Q14764