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MVP anticorps (N-Term)

MVP Reactivité: Humain, Souris, Rat, Boeuf (Vache), Lapin, Poisson zèbre (Danio rerio), Chien, Cheval, Cobaye, Porc WB Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN2787778
  • Antigène Voir toutes MVP Anticorps
    MVP (Major Vault Protein (MVP))
    Épitope
    • 10
    • 8
    • 6
    • 5
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reactivité
    • 97
    • 26
    • 24
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain, Souris, Rat, Boeuf (Vache), Lapin, Poisson zèbre (Danio rerio), Chien, Cheval, Cobaye, Porc
    Hôte
    • 63
    • 36
    • 2
    Lapin
    Clonalité
    • 51
    • 50
    Polyclonal
    Conjugué
    • 57
    • 8
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    Cet anticorp MVP est non-conjugé
    Application
    • 54
    • 37
    • 34
    • 30
    • 29
    • 19
    • 9
    • 9
    • 8
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Séquence
    MATEEFIIRI PPYHYIHVLD QNSNVSRVEV GPKTYIRQDN ERVLFAPMRM
    Homologie
    Cow: 100%, Dog: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 86%
    Attributs du produit
    This is a rabbit polyclonal antibody against MVP. It was validated on Western Blot using a cell lysate as a positive control.
    Purification
    Affinity Purified
    Immunogène
    The immunogen is a synthetic peptide directed towards the N terminal region of human MVP
    Top Product
    Discover our top product MVP Anticorps primaire
  • Indications d'application
    Optimal working dilutions should be determined experimentally by the investigator.
    Commentaires

    Antigen size: 893 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid repeated freeze-thaw cycles.
    Stock
    -20 °C
    Stockage commentaire
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Antigène
    MVP (Major Vault Protein (MVP))
    Autre désignation
    MVP (MVP Produits)
    Synonymes
    anticorps LRP, anticorps VAULT1, anticorps 2310009M24Rik, anticorps cb771, anticorps wu:fb52b05, anticorps wu:fc02g01, anticorps mvp, anticorps MGC145641, anticorps Tb05.45E22.810, anticorps major vault protein, anticorps major vault protein L homeolog, anticorps putative major vault protein, anticorps MVP, anticorps Mvp, anticorps mvp, anticorps mvp.L, anticorps Tc00.1047053510353.10, anticorps Tb927.5.4460, anticorps Tb10.70.0520, anticorps Tb10.70.5840, anticorps LMJF_05_0060
    Sujet
    MVP is required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport. MVP down-regulates INFG-mediated STAT1 signaling and subsequent activation of JAK. MVP down-regulates SRC activity and signaling through MAP kinases.This gene encodes the major vault protein which is a lung resistance-related protein. Vaults are multi-subunit structures that may be involved in nucleo-cytoplasmic transport. This protein mediates drug resistance, perhaps via a transport process. It is widely distributed in normal tissues, and overexpressed in multidrug-resistant cancer cells. The protein overexpression is a potentially useful marker of clinical drug resistance. This gene produces two transcripts by using two alternative exon 2 sequences, however, the open reading frames are the same in both transcripts.
    Alias Symbols: LRP, VAULT1
    Protein Interaction Partner: MVP, SKIL, TRIM27, REL, PLSCR1, MEOX2, MEOX1, MDFI, KPNA3, GOLGA2, DLX2, CAMK2B, AES, TRIP6, TRAF2, TP53, TFCP2, TCF4, SUMO2, NOTCH2NL, CCDC36, TRIM42, FAM154A, PIH1D2, RAB3IP, RIMBP3, C1orf94, RHOXF2, ZMIZ2, OBFC1, RFWD2, MKL1, VAC14, BANP, FAM46C, KCTD9
    Protein Size: 893
    Poids moléculaire
    98 kDa
    ID gène
    9961
    NCBI Accession
    NM_005115, NP_005106
    UniProt
    Q14764
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