WDR77 anticorps (N-Term)

N° du produit ABIN2787792

Cet anticorps anti-WDR77 est un anticorps Lapin Polyclonal détectant WDR77 dans WB. Adapté pour Humain, Souris, Rat, Boeuf (Vache), Chien, Cobaye et Lapin.

Aperçu rapide pour WDR77 anticorps (N-Term) (ABIN2787792)

Antigène: WDR77 (WD Repeat Domain 77 (WDR77))

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Chien, Cobaye, Lapin

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp WDR77 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-WDR77 anticorps

Épitope: N-Term

Séquence: MRKETPPPLV PPAAREWNLP PNAPACMERQ LEAARYRSDG ALLLGASSLS

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Human: 100%, Mouse: 93%, Rabbit: 93%, Rat: 93%

Attributs du produit: This is a rabbit polyclonal antibody against WDR77. It was validated on Western Blot.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human WDR77

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 342 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur WDR77

Antigène: WDR77 (WD Repeat Domain 77 (WDR77))

Autre désignation: WDR77

Sujet: WDR77 is the non-catalytic component of the 20S PRMT5-containing methyltransferase complex, which modifies specific arginines to dimethylarginines in several spliceosomal Sm proteins. This modification targets Sm proteins to the survival of motor neurons (SMN) complex for assembly into small nuclear ribonucleoprotein core particles. WDR77 might play a role in transcription regulation. The 20S PRMT5-containing methyltransferase complex also methylates the Piwi proteins (PIWIL1, PIWIL2 and PIWIL4), methylation of Piwi proteins being required for the interaction with Tudor domain-containing proteins and subsequent localization to the meiotic nuage.
Alias Symbols: HKMT1069, MEP50, MGC2722, Nbla10071, RP11-552M11.3, p44, MEP-50, p44/Mep50
Protein Interaction Partner: TP53, CUL3, SMAD1, AR, UBC, ASB15, WWOX, ZBTB1, SMYD1, COPS4, COPS7A, DCAF8, COPS8, PRMT5, TBC1D4, EPB41L2, HGS, FBXO6, PAN2, SNRPC, PPP1R8, POLR2C, PCBP2, HNRNPM, GRB2, QKI, TOE1, PPIL1, SAP30BP, LSM3, GPKOW, SF3A1, SF3B4, RBM5, PQBP1, THOC1, AQR, BAG2,
Protein Size: 342

Poids moléculaire: 38 kDa

ID gène: 79084

NCBI Accession: NM_024102, NP_077007

UniProt: Q9BQA1

Pathways: Ribonucleoprotein Complex Subunit Organization