WDR77 anticorps (N-Term)

N° du produit ABIN2787792

Détail du produit anti-WDR77 anticorps

Antigène: WDR77 (WD Repeat Domain 77 (WDR77))

Épitope: N-Term

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Chien, Cobaye, Lapin

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp WDR77 est non-conjugé

Application: Western Blotting (WB)

Séquence: MRKETPPPLV PPAAREWNLP PNAPACMERQ LEAARYRSDG ALLLGASSLS

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Human: 100%, Mouse: 93%, Rabbit: 93%, Rat: 93%

Attributs du produit: This is a rabbit polyclonal antibody against WDR77. It was validated on Western Blot.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human WDR77

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 342 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur WDR77

Antigène: WDR77 (WD Repeat Domain 77 (WDR77))

Autre désignation: WDR77 (WDR77 Produits)

Synonymes: anticorps MEP-50, anticorps MEP50, anticorps Nbla10071, anticorps RP11-552M11.3, anticorps p44, anticorps p44/Mep50, anticorps 2610003I18Rik, anticorps 2610312E17Rik, anticorps C79984, anticorps p44/MEP50, anticorps RGD1310479, anticorps mep50, anticorps valois, anticorps WDR77, anticorps zgc:65780, anticorps zgc:77274, anticorps WD repeat domain 77, anticorps WD repeat domain 77 S homeolog, anticorps WDR77, anticorps Wdr77, anticorps wdr77.S, anticorps wdr77

Sujet: WDR77 is the non-catalytic component of the 20S PRMT5-containing methyltransferase complex, which modifies specific arginines to dimethylarginines in several spliceosomal Sm proteins. This modification targets Sm proteins to the survival of motor neurons (SMN) complex for assembly into small nuclear ribonucleoprotein core particles. WDR77 might play a role in transcription regulation. The 20S PRMT5-containing methyltransferase complex also methylates the Piwi proteins (PIWIL1, PIWIL2 and PIWIL4), methylation of Piwi proteins being required for the interaction with Tudor domain-containing proteins and subsequent localization to the meiotic nuage.
Alias Symbols: HKMT1069, MEP50, MGC2722, Nbla10071, RP11-552M11.3, p44, MEP-50, p44/Mep50
Protein Interaction Partner: TP53, CUL3, SMAD1, AR, UBC, ASB15, WWOX, ZBTB1, SMYD1, COPS4, COPS7A, DCAF8, COPS8, PRMT5, TBC1D4, EPB41L2, HGS, FBXO6, PAN2, SNRPC, PPP1R8, POLR2C, PCBP2, HNRNPM, GRB2, QKI, TOE1, PPIL1, SAP30BP, LSM3, GPKOW, SF3A1, SF3B4, RBM5, PQBP1, THOC1, AQR, BAG2,
Protein Size: 342

Poids moléculaire: 38 kDa

ID gène: 79084

NCBI Accession: NM_024102, NP_077007

UniProt: Q9BQA1

Pathways: Ribonucleoprotein Complex Subunit Organization