CMA1 anticorps (C-Term)

N° du produit ABIN2788295

Détail du produit anti-CMA1 anticorps

Antigène: CMA1 (Chymase 1, Mast Cell (CMA1))

Épitope: C-Term

Reactivité: Humain, Souris, Rat, Lapin, Mouton, Boeuf (Vache), Chien, Cobaye

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CMA1 est non-conjugé

Application: Western Blotting (WB)

Séquence: EVKLRLMDPQ ACSHFRDFDH NLQLCVGNPR KTKSAFKGDS GGPLLCAGVA

Homologie: Cow: 86%, Dog: 100%, Guinea Pig: 86%, Human: 100%, Mouse: 79%, Rabbit: 79%, Rat: 86%, Sheep: 86%

Attributs du produit: This is a rabbit polyclonal antibody against CMA1. It was validated on Western Blot.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the C terminal region of human CMA1

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 247 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur CMA1

Antigène: CMA1 (Chymase 1, Mast Cell (CMA1))

Autre désignation: CMA1 (CMA1 Produits)

Synonymes: anticorps CYH, anticorps MCT1, anticorps chymase, anticorps MMCP-5, anticorps Mcp-5, anticorps Mcp5, anticorps Mcpt5, anticorps MCP3P, anticorps CMA1, anticorps Chymase, anticorps chymase 1, anticorps chymase 1, mast cell, anticorps chymase-like, anticorps CMA1, anticorps Cma1, anticorps LOC100008644

Sujet: CMA1 is a chymotryptic serine proteinase that belongs to the peptidase family S1. It is expressed in mast cells and thought to function in the degradation of the extracellular matrix, the regulation of submucosal gland secretion, and the generation of vasoactive peptides. In the heart and blood vessels, this protein, rather than angiotensin converting enzyme, is largely responsible for converting angiotensin I to the vasoactive peptide angiotensin II. Angiotensin II has been implicated in blood pressure control and in the pathogenesis of hypertension, cardiac hypertrophy, and heart failure. Thus, this gene product is a target for cardiovascular disease therapies.
Alias Symbols: CYH, MCT1, MGC119890, MGC119891, chymase
Protein Interaction Partner: FYN, IL1B, EDN2, EDN1, KITLG, PFN1, EDN3, MMP1, SERPINA3, AGT,
Protein Size: 247

Poids moléculaire: 27 kDa

ID gène: 1215

NCBI Accession: NM_001836, NP_001827

UniProt: P23946

Pathways: ACE Inhibitor Pathway, Peptide Hormone Metabolism, Regulation of Systemic Arterial Blood Pressure by Hormones, Carbohydrate Homeostasis