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Factor VIII anticorps (C-Term)

F8 Reactivité: Humain, Chien, Lapin, Boeuf (Vache), Mouton, Cheval WB Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN2788318
  • Antigène Voir toutes Factor VIII (F8) Anticorps
    Factor VIII (F8) (Coagulation Factor VIII (F8))
    Épitope
    • 15
    • 15
    • 15
    • 7
    • 4
    • 4
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reactivité
    • 94
    • 59
    • 30
    • 16
    • 9
    • 3
    • 1
    • 1
    • 1
    Humain, Chien, Lapin, Boeuf (Vache), Mouton, Cheval
    Hôte
    • 87
    • 21
    • 4
    • 2
    Lapin
    Clonalité
    • 94
    • 20
    Polyclonal
    Conjugué
    • 49
    • 15
    • 12
    • 5
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    Cet anticorp Factor VIII est non-conjugé
    Application
    • 54
    • 42
    • 39
    • 39
    • 24
    • 11
    • 10
    • 10
    • 10
    • 6
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Séquence
    IMVTFRNQAS RPYSFYSSLI SYEEDQRQGA EPRKNFVKPN ETKTYFWKVQ
    Homologie
    Cow: 86%, Dog: 77%, Horse: 93%, Human: 100%, Rabbit: 86%, Sheep: 86%
    Attributs du produit
    This is a rabbit polyclonal antibody against F8. It was validated on Western Blot.
    Purification
    Affinity Purified
    Immunogène
    The immunogen is a synthetic peptide directed towards the C terminal region of human F8
    Top Product
    Discover our top product F8 Anticorps primaire
  • Indications d'application
    Optimal working dilutions should be determined experimentally by the investigator.
    Commentaires

    Antigen size: 2351 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid repeated freeze-thaw cycles.
    Stock
    -20 °C
    Stockage commentaire
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Antigène
    Factor VIII (F8) (Coagulation Factor VIII (F8))
    Autre désignation
    F8 (F8 Produits)
    Synonymes
    anticorps fb61d02, anticorps wu:fb61d02, anticorps Cf-8, anticorps Cf8, anticorps FVIII, anticorps AHF, anticorps DXS1253E, anticorps F8B, anticorps F8C, anticorps HEMA, anticorps coagulation factor VIIi, anticorps coagulation factor VIII, anticorps coagulation factor VIII, procoagulant component, anticorps f7i, anticorps F8
    Sujet
    This gene encodes coagulation factor VIII, which participates in the intrinsic pathway of blood coagulation, factor VIII is a cofactor for factor IXa which, in the presence of Ca+2 and phospholipids, converts factor X to the activated form Xa. This gene produces two alternatively spliced transcripts. Transcript variant 1 encodes a large glycoprotein, isoform a, which circulates in plasma and associates with von Willebrand factor in a noncovalent complex. This protein undergoes multiple cleavage events. Transcript variant 2 encodes a putative small protein, isoform b, which consists primarily of the phospholipid binding domain of factor VIIIc. This binding domain is essential for coagulant activity. Defects in this gene results in hemophilia A, a common recessive X-linked coagulation disorder.
    Alias Symbols: AHF, DXS1253E, F8B, F8C, FVIII, HEMA
    Protein Interaction Partner: UBQLN1, GGA1, MCFD2, PHYH, LMAN1, F9, F10, VWF, F2, PROS1, PROC, HSPA5, CANX, CALR, ASGR2, LRP1,
    Protein Size: 2351
    Poids moléculaire
    79 kDa
    ID gène
    2157
    NCBI Accession
    NM_000132, NP_000123
    UniProt
    P00451
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