CTSC anticorps (Middle Region)

N° du produit ABIN2788336

Cet anticorps Lapin Polyclonal détecte spécifiquement CTSC dans WB. Il présente une réactivité envers Humain, Souris, Boeuf (Vache), Chien et Cheval.

Aperçu rapide pour CTSC anticorps (Middle Region) (ABIN2788336)

Antigène: CTSC (Cathepsin C (CTSC))

Reactivité: Humain, Souris, Boeuf (Vache), Chien, Cheval

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CTSC est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-CTSC anticorps

Épitope: Middle Region

Séquence: WTATTYMEYE TLTLGDMIRR SGGHSRKIPR PKPAPLTAEI QQKILHLPTS

Homologie: Cow: 86%, Dog: 79%, Horse: 86%, Human: 100%, Mouse: 79%

Attributs du produit: This is a rabbit polyclonal antibody against CTSC. It was validated on Western Blot.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human CTSC

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 463 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur CTSC

Antigène: CTSC (Cathepsin C (CTSC))

Autre désignation: CTSC

Sujet: CTSC is a member of the peptidase C1 family, is a lysosomal cysteine proteinase that appears to be a central coordinator for activation of many serine proteinases in immune/inflammatory cells. It is composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor, and a residual portion of the propeptide acts as an intramolecular chaperone for the folding and stabilization of the mature enzyme. This enzyme requires chloride ions for activity and can degrade glucagon. Defects in CTSC have been shown to be a cause of Papillon-Lefevre syndrome, an autosomal recessive disorder characterized by palmoplantar keratosis and periodontitis.
Alias Symbols: CPPI, DPP1, DPPI, HMS, JP, JPD, PALS, PLS, DPP-I
Protein Interaction Partner: SUMO1, UBC, NEDD8, ARMC9, ANKMY2, ARIH1, UBA2, ADSL, FBXO6, XRN2, CAPN1, CD81, CTSC, CTSL,
Protein Size: 463

Poids moléculaire: 8 kDa

ID gène: 1075

NCBI Accession: NM_001814, NP_001805

UniProt: P53634