SH2D1A anticorps (C-Term)

N° du produit ABIN2788421

L’anticorps anti-SH2D1A Polyclonal Lapin est utilisé pour la détection de SH2D1A dans des échantillons de Humain, Rat, Boeuf (Vache), Porc et Cheval. Il a été validé pour WB.

Aperçu rapide pour SH2D1A anticorps (C-Term) (ABIN2788421)

Antigène: SH2D1A (SH2 Domain Containing 1A (SH2D1A))

Reactivité: Humain, Rat, Boeuf (Vache), Porc, Cheval

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SH2D1A est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-SH2D1A anticorps

Épitope: C-Term

Fonction: SH2D1A Antibody - C-terminal region

Séquence: YFRKIKNLIS AFQKPDQGIV IPLQYPVEKK SSARSTQGTT GIREDPDVCL

Homologie: Cow: 86%, Horse: 92%, Human: 100%, Pig: 100%, Rat: 93%

Attributs du produit: This is a rabbit polyclonal antibody against SH2D1A. It was validated on Western Blot.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the C terminal region of human SH2D1A

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP60359-100UG

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: prevent freeze-thaw cycles

Stock: 4 °C,-20 °C

Stockage commentaire: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Détails sur SH2D1A

Antigène: SH2D1A (SH2 Domain Containing 1A (SH2D1A))

Autre désignation: SH2D1A

Sujet:

Background Information: SH2D1A is a protein that plays a major role in the bidirectional stimulation of T and B cells. It associates with the signaling lymphocyte-activation molecule, thereby acting as an inhibitor of this transmembrane protein by blocking the recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to its docking site. This protein can also bind to other related surface molecules that are expressed on activated T, B and NK cells, thereby modifying signal transduction pathways in these cells. Mutations in SH2D1A gene cause lymphoproliferative syndrome X-linked type 1 or Duncan disease, a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus, with symptoms including severe mononucleosis and malignant lymphoma.

Gene Name: SH2 domain containing 1A

Alternative Symbols: LYP, SAP, XLP, DSHP, EBVS, IMD5, XLPD, MTCP1, XLPD1, SAP/SH2D1A

Protein Name: SH2 domain-containing protein 1A

Poids moléculaire: 14kDa

ID gène: 4068

NCBI Accession: NP_002342

UniProt: O60880

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process