TCHP anticorps (C-Term)

N° du produit ABIN2788476

Détail du produit anti-TCHP anticorps

Antigène: TCHP (Trichoplein, Keratin Filament Binding (TCHP))

Épitope: C-Term

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Chien, Cobaye, Cheval, Lapin, Saccharomyces cerevisiae

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TCHP est non-conjugé

Application: Western Blotting (WB)

Séquence: IQEKIEQNRR AQEESLKHRE QLIRNLEEVR ELARREKEES EKLKSARKQE

Homologie: Cow: 100%, Dog: 86%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 86%, Rat: 100%, Yeast: 91%

Attributs du produit: This is a rabbit polyclonal antibody against TCHP. It was validated on Western Blot.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the C terminal region of human TCHP

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 498 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-TCHP (ABIN2788476)

Wong, Vaz, Lee, Zhao, Luo, Archer, Preiss, Tanavde, Vardy: "Embryonic Stem Cells Exhibit mRNA Isoform Specific Translational Regulation." dans: PLoS ONE, Vol. 11, Issue 1, pp. e0143235, (2016) (PubMed).

Détails sur TCHP

Antigène: TCHP (Trichoplein, Keratin Filament Binding (TCHP))

Autre désignation: TCHP (TCHP Produits)

Synonymes: anticorps TpMs, anticorps A930031F18Rik, anticorps AV279199, anticorps RGD1310813, anticorps zgc:136634, anticorps trichoplein keratin filament binding, anticorps trichoplein, keratin filament binding, anticorps trichoplein, keratin filament binding L homeolog, anticorps TCHP, anticorps tchp, anticorps Tchp, anticorps tchp.L

Sujet: TCHP is a tumor suppressor which has the ability to inhibit cell growth and be pro-apoptotic during cell stress. It inhibits cell growth in bladder and prostate cancer cells by a down-regulation of HSPB1 by inhibiting its phosphorylation. It may act as a 'capping' or 'branching' protein for keratin filaments in the cell periphery. And it also may regulate K8/K18 filament and desmosome organization mainly at the apical or peripheral regions of simple epithelial cells.
Alias Symbols: MGC10854, TpMs
Protein Interaction Partner: CCDC172, MIPOL1, DYDC1, KRT40, LZTS2, NME7, NDOR1, MKRN3, TRIM27, NAB2, KRT15, CDR2, UBC, LATS2, CUL4A, CCDC85B, TEX11, VIM, KRT18, KRT16, KRT14, KRT8, KRT6A, KRT5,
Protein Size: 498

Poids moléculaire: 61 kDa

ID gène: 84260

NCBI Accession: NM_032300, NP_115676

UniProt: Q9BT92