Histone H3.3 anticorps (N-Term)

N° du produit ABIN2788643

Cet anticorps anti-Histone H3.3 est un anticorps Lapin Polyclonal détectant Histone H3.3 dans WB. Adapté pour Rat, Porc, Poisson zèbre (Danio rerio) et Chien.

Aperçu rapide pour Histone H3.3 anticorps (N-Term) (ABIN2788643)

Antigène: Histone H3.3 (H3F3A) (H3 Histone, Family 3A (H3F3A))

Reactivité: Rat, Porc, Poisson zèbre (Danio rerio), Chien

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Histone H3.3 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-Histone H3.3 anticorps

Épitope: N-Term

Séquence: KSAPSTGGVK KPHRYRPGTV ALREIRRYQK STELLIRKLP FQRLVREIAQ

Homologie: Dog: 100%, Pig: 100%, Rat: 100%, Zebrafish: 100%

Attributs du produit: This is a rabbit polyclonal antibody against H3f3a. It was validated on Western Blot.

Purification: Affinity Purified

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 126 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur Histone H3.3

Antigène: Histone H3.3 (H3F3A) (H3 Histone, Family 3A (H3F3A))

Autre désignation: H3f3a

Sujet: H3f3a is a variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. H3f3a constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. H3f3a is deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Alias Symbols: H3.3A, H3f3b, MGC102150
Protein Interaction Partner: Kmt2d, Chd5, Setd1a, Kmt2c, Setd1b, Ezh2, Chd1, Cbx3, Uhrf1, Nfkb2, Hdac5, Hdac3, Kdm6b, Nfe2, Aurka, Cbx2, Ehmt2, Cbx5, Aurkb, Cbx6, Bptf, Creb3l4, Ing2, Cbx7, Cbx8, Cbx4, Cd4, Fosb, Rps6ka5, Rps6ka3, Igh-8, Cd79a, Tcrb, Eif2s3x, Kdm5c, Nanog, Kcnq1ot1,
Protein Size: 126

Poids moléculaire: 15 kDa

ID gène: 15078

NCBI Accession: NM_008210, NP_032236

UniProt: P84244