GALR2 anticorps (C-Term)

N° du produit ABIN2788788

Détail du produit anti-GALR2 anticorps

Antigène: GALR2 (Galanin Receptor 2 (GALR2))

Épitope: C-Term

Reactivité: Humain, Cheval

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GALR2 est non-conjugé

Application: Western Blotting (WB)

Séquence: RGTHSGSVLE RESSDLLHMS EAAGALRPCP GASQPCILEP CPGPSWQGPK

Homologie: Horse: 93%, Human: 100%

Attributs du produit: This is a rabbit polyclonal antibody against GALR2. It was validated on Western Blot.

Purification: Affinity Purified

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 387 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur GALR2

Antigène: GALR2 (Galanin Receptor 2 (GALR2))

Autre désignation: GALR2 (GALR2 Produits)

Synonymes: anticorps GALNR2, anticorps mGalR, anticorps GALR2, anticorps GAL2-R, anticorps GALR-2, anticorps galanin receptor 2, anticorps transcription regulator. LacI family, raffinose related, anticorps DNA-binding transcriptional regulator GalR, anticorps galactose operon repressor, anticorps galanin receptor type 2, anticorps GALR2, anticorps Galr2, anticorps LOC100037698, anticorps rafR, anticorps galR2, anticorps LOC103690156

Sujet: Galanin is an important neuromodulator present in the brain, gastrointestinal system, and hypothalamopituitary axis. It is a 30-amino acid non-C-terminally amidated peptide that potently stimulates growth hormone secretion, inhibits cardiac vagal slowing of heart rate, abolishes sinus arrhythmia, and inhibits postprandial gastrointestinal motility. The actions of galanin are mediated through interaction with specific membrane receptors that are members of the 7-transmembrane family of G protein-coupled receptors. GALR2 interacts with the N-terminal residues of the galanin peptide. The primary signaling mechanism for GALR2 is through the phospholipase C/protein kinase C pathway (via Gq), in contrast to GALR1, which communicates its intracellular signal by inhibition of adenylyl cyclase through Gi. However, it has been demonstrated that GALR2 couples efficiently to both the Gq and Gi proteins to simultaneously activate 2 independent signal transduction pathways.
Alias Symbols: GALNR2, MGC125983, MGC125984
Protein Interaction Partner: GNAQ, GAL,
Protein Size: 387

Poids moléculaire: 43 kDa

ID gène: 8811

NCBI Accession: NM_003857, NP_003848

UniProt: O43603

Pathways: cAMP Metabolic Process, Inositol Metabolic Process, Feeding Behaviour