PKN2 anticorps (C-Term)

N° du produit ABIN2788942

Détail du produit anti-PKN2 anticorps

Antigène: PKN2 (Protein Kinase N2 (PKN2))

Épitope: C-Term

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Cheval, Lapin, Poisson zèbre (Danio rerio), Chien, Cobaye, Saccharomyces cerevisiae

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PKN2 est non-conjugé

Application: Western Blotting (WB)

Séquence: LRRNPERRLG AGEKDAEDVK KHPFFRLTDW SALMDKKVKP PFVPTIRGRE

Homologie: Cow: 93%, Dog: 93%, Guinea Pig: 93%, Horse: 93%, Human: 100%, Mouse: 93%, Rabbit: 93%, Rat: 93%, Yeast: 77%, Zebrafish: 93%

Attributs du produit: This is a rabbit polyclonal antibody against Pkn2. It was validated on Western Blot.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the C-terminal region of Mouse Pkn2

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeat freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur PKN2

Antigène: PKN2 (Protein Kinase N2 (PKN2))

Autre désignation: Pkn2 (PKN2 Produits)

Synonymes: anticorps PAK2, anticorps PRK2, anticorps PRKCL2, anticorps PRO2042, anticorps Pak-2, anticorps 6030436C20Rik, anticorps AI507382, anticorps Prkcl2, anticorps Stk7, anticorps pak2, anticorps prk2, anticorps pak-2, anticorps pro2042, anticorps PKN2, anticorps si:ch211-83f14.1, anticorps wu:fa97c07, anticorps protein kinase N2, anticorps protein kinase N2 L homeolog, anticorps PKN2, anticorps Pkn2, anticorps pkn2.L, anticorps pkn2

Sujet: Pkn2 is a PKC-related serine/threonine-protein kinase and Rho/Rac effector protein that participates in specific signal transduction responses in the cell. It plays a role in the regulation of cell cycle progression, actin cytoskeleton assembly, cell migration, cell adhesion, tumor cell invasion and transcription activation signaling processes. Pkn2 phosphorylates CTTN in hyaluronan-induced astrocytes and hence decreases CTTN ability to associate with filamentous actin, phosphorylates HDAC5, therefore lead to impair HDAC5 import. It is a direct RhoA target required for the regulation of the maturation of primordial junctions into apical junction formation in bronchial epithelial cells and is required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner. It stimulates FYN kinase activity that is required for establishment of skin cell-cell adhesion during keratinocytes differentiation, regulates epithelial bladder cells speed and direction of movement during cell migration and tumor cell invasion, inhibits Akt pro-survival-induced kinase activity. It mediates Rho protein-induced transcriptional activation via the c-fos serum response factor (SRF).
Alias Symbols: 6030436C20Rik, AI507382, PRK2, Prkcl2, Stk7
Protein Size: 983

Poids moléculaire: 111 kDa

ID gène: 109333

NCBI Accession: NM_178654, NP_848769

UniProt: Q8BWW9

Pathways: Cell-Cell Junction Organization