PKN2 anticorps (C-Term)

N° du produit ABIN2788942

Cet anticorps anti-PKN2 Polyclonal Lapin (ABIN2788942) détecte spécifiquement PKN2 dans WB. L’anticorps est réactif avec des échantillons de Humain, Souris, Rat, Boeuf (Vache), Cheval, Lapin, Poisson zèbre (Danio rerio), Chien, Cobaye et Saccharomyces cerevisiae.

Aperçu rapide pour PKN2 anticorps (C-Term) (ABIN2788942)

Antigène: PKN2 (Protein Kinase N2 (PKN2))

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Cheval, Lapin, Poisson zèbre (Danio rerio), Chien, Cobaye, Saccharomyces cerevisiae

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PKN2 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-PKN2 anticorps

Épitope: C-Term

Fonction: Pkn2 Antibody - C-terminal region

Séquence: LRRNPERRLG AGEKDAEDVK KHPFFRLTDW SALMDKKVKP PFVPTIRGRE

Homologie: Cow: 93%, Dog: 93%, Guinea Pig: 93%, Horse: 93%, Human: 100%, Mouse: 93%, Rabbit: 93%, Rat: 93%, Yeast: 77%, Zebrafish: 93%

Attributs du produit: This is a rabbit polyclonal antibody against Pkn2. It was validated on Western Blot.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the C-terminal region of Mouse Pkn2

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP61895-100UG

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: prevent freeze-thaw cycles

Stock: 4 °C,-20 °C

Stockage commentaire: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Détails sur PKN2

Antigène: PKN2 (Protein Kinase N2 (PKN2))

Autre désignation: Pkn2

Sujet:

Background Information: Pkn2 is a PKC-related serine/threonine-protein kinase and Rho/Rac effector protein that participates in specific signal transduction responses in the cell. It plays a role in the regulation of cell cycle progression, actin cytoskeleton assembly, cell migration, cell adhesion, tumor cell invasion and transcription activation signaling processes. Pkn2 phosphorylates CTTN in hyaluronan-induced astrocytes and hence decreases CTTN ability to associate with filamentous actin, phosphorylates HDAC5, therefore lead to impair HDAC5 import. It is a direct RhoA target required for the regulation of the maturation of primordial junctions into apical junction formation in bronchial epithelial cells and is required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner. It stimulates FYN kinase activity that is required for establishment of skin cell-cell adhesion during keratinocytes differentiation, regulates epithelial bladder cells speed and direction of movement during cell migration and tumor cell invasion, inhibits Akt pro-survival-induced kinase activity. It mediates Rho protein-induced transcriptional activation via the c-fos serum response factor (SRF).

Gene Name: protein kinase N2

Alternative Symbols: PR, Prk, Stk, PRK2, Stk7, Prkcl2, AI507382, 6030436C20Rik

Protein Name: Serine/threonine-protein kinase N2

Poids moléculaire: 111kDa

ID gène: 109333

NCBI Accession: NP_848769

UniProt: Q8BWW9

Pathways: Cell-Cell Junction Organization