BAG4 anticorps (C-Term)

N° du produit ABIN2788953

Cet anticorps Lapin Polyclonal détecte spécifiquement BAG4 dans WB. Il présente une réactivité avec des échantillons de Humain, Rat, Boeuf (Vache), Chien, Cheval, Cobaye, Lapin et Porc.

Aperçu rapide pour BAG4 anticorps (C-Term) (ABIN2788953)

Antigène: BAG4 (BCL2-Associated Athanogene 4 (BAG4))

Reactivité: Humain, Rat, Boeuf (Vache), Chien, Cheval, Cobaye, Lapin, Porc

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp BAG4 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-BAG4 anticorps

Épitope: C-Term

Fonction: BAG4 Antibody - C-terminal region

Séquence: PSAPPGNLYM TESTSPWPSS GSPQSPPSPP VQQPKDSSYP YSQSDQSMNR

Homologie: Cow: 91%, Dog: 100%, Guinea Pig: 77%, Horse: 92%, Human: 100%, Pig: 100%, Rabbit: 92%, Rat: 92%

Attributs du produit: This is a rabbit polyclonal antibody against BAG4. It was validated on Western Blot.

Purification: Affinity Purified

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP61938-100UG

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: prevent freeze-thaw cycles

Stock: 4 °C,-20 °C

Stockage commentaire: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Détails sur BAG4

Antigène: BAG4 (BCL2-Associated Athanogene 4 (BAG4))

Autre désignation: BAG4

Sujet:

Background Information: The protein encoded by this gene is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein that functions through interactions with a variety of cell apoptosis and growth related proteins including BCL-2, Raf-protein kinase, steroid hormone receptors, growth factor receptors and members of the heat shock protein 70 kDa family. This protein contains a BAG domain near the C-terminus, which could bind and inhibit the chaperone activity of Hsc70/Hsp70. This protein was found to be associated with the death domain of tumor necrosis factor receptor type 1 (TNF-R1) and death receptor-3 (DR3), and thereby negatively regulates downstream cell death signaling. The regulatory role of this protein in cell death was demonstrated in epithelial cells which undergo apoptosis while integrin mediated matrix contacts are lost. Alternatively spliced transcript variants encoding distinct isoforms have been identified.

Gene Name: BCL2-associated athanogene 4

Alternative Symbols: SODD, BAG-4

Protein Name: BAG family molecular chaperone regulator 4

Poids moléculaire: 46kDa

ID gène: 9530

NCBI Accession: NP_001191807

UniProt: B4E217

Pathways: Regulation of Actin Filament Polymerization